Galicaftor
Small moleculeexperimental
Clinical trial activity
12 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Jan 1, 2016 (NCT02662452)
Timeline
Indications
Mechanism of action
CFTR inhibitor
- Cystic fibrosis transmembrane conductance regulatorPOSITIVE MODULATOR
Cystic fibrosis transmembrane conductance regulator positive modulator
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)c1ccc([C@H]2C[C@@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c3ccc(OC(F)F)cc3O2)cc1- Mol. weight
- 559.47 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4101487 ↗
Also known as
- glpg2222
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07035990 | Phase 1 | Jul 23, 2025 | Nucleus Network Ltd, Sionna Therapeutics Inc. |
| NCT05538585 | Phase 1 | Sep 27, 2022 | AbbVie |
| NCT05530278 | Phase 1 | Sep 20, 2022 | AbbVie |
| NCT04853368 | Phase 2 | Sep 13, 2021 | AbbVie |
| NCT03969888 | Phase 2 | Aug 27, 2019 | AbbVie |
| NCT03540524 | Phase 1 | May 31, 2018 | Galapagos NV |
| NCT03128606 | Phase 1 | Mar 28, 2017 | Galapagos NV |
| NCT03119649 | Phase 2 | Mar 18, 2017 | Galapagos NV |
| NCT03045523 | Phase 2 | Jan 1, 2017 | Galapagos NV |
| NCT03214614 | Phase 1 | Nov 14, 2016 | Galapagos NV |
| NCT02788721 | Phase 1 | May 1, 2016 | Galapagos NV, Pharmaceutical Research Associates, Inc. (PRA), SGS Life Sciences |
| NCT02662452 | Phase 1 | Jan 1, 2016 | Galapagos NV |
Showing 12 of 12 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Galapagos NV | For profit | 7 | 7 | 2 | 2016 |
| AbbVie | For profit | 4 | 4 | 2 | 2019 |
| Nucleus Network Ltd | For profit | 1 | 0 | 1 | 2025 |
| Pharmaceutical Research Associates, Inc. (PRA) | For profit | 1 | 0 | 1 | 2016 |
| SGS Life Sciences | For profit | 1 | 0 | 1 | 2016 |
| Sionna Therapeutics Inc. | For profit | 1 | 1 | 1 | 2025 |
6 organizations
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