CDEK
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Nesolicaftor

Small moleculeexperimental

Clinical trial activity

7 trials · 5 clinical orgs · 0 marketing orgs

Phase 1
5
Phase 2
3
Phase 3
0
Phase 4
0

Earliest trial started Jun 1, 2016 (NCT02846142)

Timeline

2010s

  1. Jan 1, 2016

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2018

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C[C@@H](O)c1nnc([C@H]2C[C@H](NC(=O)c3cc(-c4ccccc4)no3)C2)o1
Mol. weight
354.37 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • pti-428

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06468527Phase 2Jun 3, 2024European Union, Utrecht University
NCT03591094Phase 2Aug 21, 2018Proteostasis Therapeutics
NCT03500263Phase 1Jan 30, 2018Proteostasis Therapeutics
NCT03258424Phase 1Jul 28, 2017Proteostasis Therapeutics
NCT03251092Phase 1Jul 17, 2017ICON, Medical University of South Carolina, Proteostasis Therapeutics
NCT02718495Phase 1/Phase 2 (Phase 2)Jul 19, 2016Proteostasis Therapeutics
NCT02846142Phase 1Jun 1, 2016Proteostasis Therapeutics
Showing 7 of 7 trials
Page 1 / 1

Organizations

Research & Development (5)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Proteostasis TherapeuticsFor profit6622016
European UnionGovernment1012024
ICONFor profit1012017
Medical University of South CarolinaAcademic/Hospital1012017
Utrecht UniversityAcademic/Hospital1112024
5 organizations
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