Posenacaftor
Small moleculeexperimental
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Apr 10, 2017 (NCT03140527)
Timeline
Indications
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
Cc1c(-c2cc(C(=O)O)c3c(O[C@H](C)C4CCOCC4)ccc(C)c3n2)oc2ccccc12- Mol. weight
- 445.52 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4594274 ↗
Also known as
- pti-801
- pti-801
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06468527 | Phase 2 | Jun 3, 2024 | European Union, Utrecht University |
| NCT03500263 | Phase 1 | Jan 30, 2018 | Proteostasis Therapeutics |
| NCT03251092 | Phase 1 | Jul 17, 2017 | ICON, Medical University of South Carolina, Proteostasis Therapeutics |
| NCT03140527 | Phase 1 | Apr 10, 2017 | Proteostasis Therapeutics |
Showing 4 of 4 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Proteostasis Therapeutics | For profit | 3 | 3 | 1 | 2017 |
| European Union | Government | 1 | 0 | 1 | 2024 |
| ICON | For profit | 1 | 0 | 1 | 2017 |
| Medical University of South Carolina | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Utrecht University | Academic/Hospital | 1 | 1 | 1 | 2024 |
5 organizations
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