CDEK
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salicylic acid

Small moleculemarketed

Approved

Jun 1, 1829

Calcium salicylate is the calcium salt of salicylic acid. The anti-cancer effectiveness of calcium salicylate has been investigated on human HT-1080 fibrosarcoma cell lines. Low calcium salicylate concentrations did not retard tumor growth progression significantly but its cytotoxic characteristics were proven to be prominent by various morphological and immunocytological techniques - approximately 25% apoptosis after treatment with calcium salicylate. This compound up-regulated the expression of p53, p21 and Bax, and down-regulated Bcl-2 in HT-1080 cells. In addition, calcium salicylate is used in root canal filling material development. — NCATS

Clinical trial activity

51 trials · 49 clinical orgs · 0 marketing orgs

Phase 1
10
Phase 2
17
Phase 3
10
Phase 4
10

Earliest trial started Aug 1, 1999 (NCT00004245)

Timeline

1820s

  1. Jun 1, 1829

    Evidence of US Marketing

1990s

  1. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

2000s

  1. Jan 1, 2000

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2006

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedJun 1, 1829

Chemistry & pharmacology

Loading structure…

SMILES

[Ca++].OC1=C(C=CC=C1)C([O-])=O.OC2=C(C=CC=C2)C([O-])=O
Mol. weight
314.304 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 2-carboxyphenol
  • 2-carboxyphenol
  • 2-carboxyphenol
  • 2-hydroxy-benzoic acid
  • 2-hydroxy-benzoic acid
  • 2-hydroxybenzoic acid
  • 2-hydroxybenzoic acid
  • 2-hydroxybenzoic acid
  • acnisal
  • advanced pain relief callus removers
  • advanced pain relief callus removers
  • advanced pain relief com removers
  • alysine
  • alysine
  • atopiclair
  • atopiclair
  • bazuka
  • bazuka
  • clear away wart remover
  • clear away wart remover
  • compound v
  • compound v
  • compound w
  • cuplex verruca
  • diprosalic
  • diprosalic
  • dr. scholl's callus removers
  • dr. scholl's callus removers
  • dr. scholl's corn removers
  • dr. scholl's corn removers
  • dr. scholl's wart remover kit
  • dr. scholl's wart remover kit
  • duofilm
  • duofilm
  • duofilm
  • duofilm wart remover
  • duoplant
  • duoplant
  • edinburgh
  • edinburgh
  • erytex
  • folrex
  • freezone
  • freezone
  • gppe paint
  • ionil
  • ionil
  • ionil-plus
  • ionil-plus
  • keralyt
  • keralyt
  • mas063dp
  • metanium
  • necol
  • noxacorn
  • o-carboxyphenol
  • o-carboxyphenol
  • occlusal
  • occlusal
  • o-hydroxybenzoic acid
  • o-hydroxybenzoic acid
  • phiso-clear
  • phytocil
  • posalfilin
  • pyralvex
  • salactol
  • salactol
  • salatac
  • salicyclic acid
  • salicyclic acid
  • salicylate
  • salicylate
  • salicylic acid
  • salicylic acid
  • salicylic acid
  • salicylic acid
  • salicylic acid
  • salicylic acid
  • salicylic acid
  • salicylic acid soap
  • salicylic acid soap
  • saligel
  • saligel
  • sodium salicylate
  • sodium salicylate
  • sodium salicylate
  • sodium salicylate
  • sodium salicylate
  • sod sal
  • stri-dex
  • stri-dex
  • thwart
  • toepedo
  • verrugon
  • verrugon
  • wartex
  • zarzenda
  • zarzenda

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07264595Phase 1/Phase 2 (Phase 2)Dec 31, 2025GeneScience Pharmaceuticals Co., Ltd.
NCT07259564Phase 2Dec 19, 2025GeneScience Pharmaceuticals Co., Ltd.
NCT06969300N/ADec 1, 2023Jiao Tong University
NCT05921890Phase 1Jun 19, 2023GeneScience Pharmaceuticals Co., Ltd.
NCT06925035N/AJun 1, 2023Jiao Tong University
NCT05617950N/ANov 30, 2022People's Liberation Army of China
NCT05503706N/ASep 30, 2022L'Oreal
NCT05611281Phase 1Sep 22, 2022GeneScience Pharmaceuticals Co., Ltd.
NCT05536193Phase 4Sep 10, 2022Assiut University
NCT06307223Phase 4Jun 7, 2022Jiao Tong University
NCT05712837N/AJun 1, 2022Government of Pakistan
NCT05428202Phase 1Mar 28, 2022Erciyes University, MonitorCRO
NCT05588999Phase 1Mar 1, 2022Government of Pakistan
NCT04889703N/ADec 31, 2021The University of Texas, Dallas
NCT04429308Phase 2Jan 31, 2021Northwestern University
NCT07062120N/AJan 1, 2021Jiao Tong University
NCT04601259N/AOct 21, 2020Carlanderska Hospital, Orkla Health
NCT03859843Phase 3Jan 10, 2020Assiut University
NCT03832647Phase 4Feb 18, 2019Vichy Laboratoires
NCT05862441Phase 2/Phase 3 (Phase 3)Jan 1, 2018University of Antwerp
Showing 20 of 51 trials
Page 1 / 3

Organizations

Research & Development (49)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
GeneScience Pharmaceuticals Co., Ltd.For profit4422022
Jiao Tong UniversityAcademic/Hospital4422021
Northwestern UniversityAcademic/Hospital3322008
Assiut UniversityAcademic/Hospital2222020
AzidusFor profit2222006
Bangladesh Medical UniversityAcademic/Hospital2222013
Government of PakistanGovernment2222022
The University of Texas, DallasAcademic/Hospital2222008
AlmirallFor profit1112014
BayerFor profit1112007
Boston UniversityAcademic/Hospital1112017
Cairo UniversityAcademic/Hospital1112016
Carlanderska HospitalAcademic/Hospital1012020
Catalysis SLFor profit1112009
Cornell UniversityAcademic/Hospital1111999
Erciyes UniversityAcademic/Hospital1112022
GaldermaFor profit1112016
GlaxoSmithKlineFor profit1112014
G. Pohl-Boskamp GmbH & Co. KGFor profit1112013
Grossman, Michael, D.P.M.Academic/Hospital1112011
49 organizations
Page 1 / 3