platelet-rich plasma
Human platelet lysate is a substitute supplement for fetal bovine serum (FBS) in experimental and clinical cell culture. It is a turbid, light-yellow liquid that is obtained from human blood platelets after freeze/thaw cycle(s). The freeze/thaw cycle causes the platelets to lyse, releasing a large quantity of growth factors necessary for cell expansion. hPL has the highest concentration of growth factors of any serum supplements. FBS-free cell culture media, e.g. with platelet lysate or chemically defined/ animal component free, are used for cell therapy or regenerative medicine. They are commercially available in GMP -quality which is generally basis for regulatory approval. — Wikipedia
Clinical trial activity
506 trials · 370 clinical orgs · 0 marketing orgs
Earliest trial started Jun 1, 2005 (NCT00856934)
Timeline
Indications
Approved for
Studied for
- Achilles Tendon · Phase 4
- Acne Vulgaris · Phase 3
- Adrenal Cortex Hormones · Phase 4
- Airway Extubation · Phase 1/Phase 2
- Allogeneic Cells · Phase 1/Phase 2
- Alopecia · Phase 4
- Alopecia Areata · Phase 4
- Alveolar Bone Loss · Phase 2/Phase 3
- Amenorrhea · Phase 2/Phase 3
- Anosmia · Phase 3
- Anterior Cruciate Ligament Injuries · Phase 4
- Aortic Dissection · Phase 2/Phase 3
- Arthritis · Phase 4
- Arthritis, Rheumatoid · Phase 1
- Arthroplasty · Early Phase 1
- Athletic Injuries · Phase 1
- Atrophic Vaginitis · Phase 1
- Back Injuries · Phase 4
- Back Pain · Phase 4
- Blood Platelets · Phase 4
- Bone Resorption · Phase 1
- Breast Neoplasms · Phase 4
- Bruxism · Phase 2/Phase 3
- Bursitis · Early Phase 1
- Carpal Tunnel Syndrome · Phase 4
- Cartilage, Articular · Phase 2
- Cartilage Diseases · Phase 4
- Cesarean Section · Phase 2
- Chronic Disease · Phase 2
- Chronic Limb-Threatening Ischemia · Phase 1/Phase 2
- Chronic Pain · Phase 4
- Cicatrix, Hypertrophic · Phase 2
- Cleft Lip · Phase 2
- Colitis, Ulcerative · Phase 1
- Congenital Microtia · Early Phase 1
- Corneal Diseases · Phase 4
- Corneal Ulcer · Phase 4
- COVID-19 · Phase 2/Phase 3
- Cystitis, Interstitial · Phase 3
- Dental Implantation · Phase 3
- Dermatology · Phase 1/Phase 2
- Diabetes Complications · Phase 1
- Diabetes, Gestational · Phase 2/Phase 3
- Diabetes Mellitus · Phase 2/Phase 3
- Diabetes Mellitus, Type 1 · Phase 1/Phase 2
- Diabetes Mellitus, Type 2 · Phase 4
- Diabetic Foot · Phase 3
- Diabetic Retinopathy · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 2
- Dry Eye Syndromes · Phase 4
- Elbow · Phase 4
- Elbow Tendinopathy · Phase 4
- Embryo Transfer · Phase 4
- Endometrial Neoplasms · Phase 2
- Endometriosis · Phase 1/Phase 2
- Endometrium · Phase 2
- Endoscopic Mucosal Resection · Phase 3
- Erectile Dysfunction · Phase 3
- Facial Injuries · Phase 3
- Fasciitis, Plantar · Phase 4
- Fat Body · Phase 2/Phase 3
- Fecal Incontinence · Early Phase 1
- Female · Phase 2
- Femoracetabular Impingement · Phase 4
- Fertilization in Vitro · Phase 3
- Fissure in Ano · Phase 4
- Foot Ulcer · Phase 1
- Genital Diseases, Male · Phase 2
- Graft vs Host Disease · Phase 2
- Gynatresia · Phase 2
- Headache · Phase 1
- Hearing Loss · Phase 2/Phase 3
- Hearing Loss, Sensorineural · Phase 2/Phase 3
- Hearing Loss, Sudden · Phase 2/Phase 3
- Hyaluronic Acid · Phase 4
- Hyperpigmentation · Phase 2
- Infant, Premature · Phase 1
- Infections · Phase 4
- Infertility · Phase 4
- Infertility, Female · Phase 2/Phase 3
- Injections, Intra-Articular · Phase 4
- Intervertebral Disc Degeneration · Phase 3
- Joint Diseases · Phase 2
- Keratomileusis, Laser In Situ · Phase 2
- Kidney Diseases · Phase 4
- Knee Injuries · Phase 4
- Leg Ulcer · Phase 1
- Lichen Planus · Phase 2
- Lipids · Phase 2/Phase 3
- Losartan · Phase 4
- Low Back Pain · Phase 4
- Melanosis · Phase 3
- Meniscus · Phase 4
- Menopause · Phase 2/Phase 3
- Menopause, Premature · Phase 2/Phase 3
- Menstrual Cycle · Phase 2/Phase 3
- Multiple Organ Failure · Early Phase 1
- Muscles · Phase 3
- Musculoskeletal Diseases · Phase 2
- Myalgia · Phase 2/Phase 3
- Myofascial Pain Syndromes · Phase 2/Phase 3
- Nasolabial Fold · Phase 1/Phase 2
- Neck Pain · Phase 2/Phase 3
- Neuralgia · Phase 1
- Olfactory Nerve Diseases · Phase 3
- Olfactory Nerve Injuries · Phase 3
- Orthodontic Appliances, Removable · Phase 3
- Osteoarthritis · Phase 4
- Osteoarthritis, Hip · Phase 3
- Osteoarthritis, Knee · Phase 4
- Osteochondroma · Phase 1
- Otitis Media · Phase 2/Phase 3
- Ovarian Diseases · Phase 2/Phase 3
- Ovulation · Phase 2/Phase 3
- Pain · Phase 4
- Pelvic Floor Disorders · Phase 2/Phase 3
- Pemphigus · Phase 3
- Penile Induration · Phase 2
- Peptic Ulcer · Phase 1/Phase 2
- Peripheral Arterial Disease · Phase 1/Phase 2
- Pharmacokinetics · Phase 3
- Platelet-Rich Plasma · Phase 4
- Pleural Effusion · Phase 2
- Pneumothorax · Phase 1/Phase 2
- Popliteal Cyst · Phase 3
- Positron-Emission Tomography · Phase 1
- Postmenopause · Phase 1
- Postoperative Pain · Phase 4
- Pregnancy Outcome · Phase 2
- Primary Ovarian Insufficiency · Phase 2/Phase 3
- Rectal Diseases · Phase 1
- Rectal Fistula · Phase 4
- Respiratory Distress Syndrome · Phase 1/Phase 2
- Rhytidoplasty · Early Phase 1
- Rotator Cuff · Phase 2
- Rotator Cuff Injuries · Phase 4
- Sacroiliitis · Phase 4
- Sexual Dysfunction, Physiological · Phase 2
- Shoulder Injuries · Phase 3
- Shoulder Pain · Phase 4
- Sjogren's Syndrome · Phase 3
- Skin Aging · Phase 1/Phase 2
- Spinal Cord Injuries · Phase 1
- Spondylosis · Phase 1
- Sports Medicine · Phase 4
- Sprains and Strains · Phase 4
- Steroids · Phase 4
- Stromal Vascular Fraction · Phase 1
- Temporomandibular Joint Disorders · Phase 4
- Tendinopathy · Phase 4
- Tennis Elbow · Phase 3
- Therapeutics · Phase 4
- Tissue Adhesions · Phase 2
- Tooth Abnormalities · Phase 4
- Tooth Loss · Phase 2/Phase 3
- Traumatology · Phase 1
- Trigger Finger Disorder · Phase 3
- Tympanic Membrane Perforation · Phase 2/Phase 3
- Ulcer · Phase 3
- Ultrasonography · Phase 4
- Urinary Incontinence · Phase 2/Phase 3
- Urinary Incontinence, Stress · Phase 2/Phase 3
- Vaginitis · Phase 1
- Varicose Ulcer · Phase 3
- Vision, Ocular · Phase 1/Phase 2
- Vulvar Lichen Sclerosus · Phase 2
- Warts · Phase 4
- Wound Healing · Phase 2/Phase 3
- Wounds and Injuries · Phase 2/Phase 3
Mechanism of action
- PlasmaSupplementation
Plasma supplementation
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPlatelet lysate ↗
- NCATSZW1U5HYZ1A ↗
- WikipediaPlatelet-rich plasma ↗
Also known as
- autologous human platelet lysate
- autologous platelet rich plasma
- autologous platelet-rich plasma
- l-prp
- plasma rich platelet
- platelet lysate
- platelet rich plasma
- platelet-rich plasma
- platelet-rich-plasma
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07020559 | Phase 4 | Apr 30, 2026 | Peking University |
| NCT07277998 | N/A | Mar 31, 2026 | Karachi Medical and Dental College |
| NCT07306871 | N/A | Jan 1, 2026 | Minia University |
| NCT07282288 | N/A | Dec 15, 2025 | Peking University |
| NCT07231471 | N/A | Dec 15, 2025 | University of Utah |
| NCT07151703 | Phase 3 | Oct 1, 2025 | Taipei Veteran General hospital |
| NCT06998433 | Phase 4 | Sep 30, 2025 | Baylor University |
| NCT07115797 | N/A | Sep 30, 2025 | Cairo University |
| NCT06903611 | Phase 3 | Sep 30, 2025 | Cambium Bio Limited |
| NCT07117955 | N/A | Sep 20, 2025 | University of Copenhagen |
| NCT07185802 | N/A | Aug 27, 2025 | Bangladesh Medical University |
| NCT07107399 | Phase 2/Phase 3 (Phase 3) | Aug 5, 2025 | Cairo University |
| NCT07103551 | Phase 3 | Aug 1, 2025 | Al Azhar University |
| NCT07307118 | N/A | Jul 8, 2025 | Firat University |
| NCT06924853 | N/A | Jul 1, 2025 | Regenexx |
| NCT07005661 | Phase 2/Phase 3 (Phase 3) | Jun 30, 2025 | Capital Medical University, Central South University, Guangzhou Medical University, Shantou University |
| NCT06372600 | N/A | Jun 1, 2025 | Chengdu Sport University |
| NCT06907121 | Phase 2/Phase 3 (Phase 3) | Jun 1, 2025 | Integrant Pty Ltd, University of Technology, Sydney |
| NCT06930248 | N/A | May 1, 2025 | Sohag University |
| NCT06965088 | Phase 2 | Apr 28, 2025 | Mahidol University |
Organizations
Research & Development (370)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Assiut University | Academic/Hospital | 16 | 16 | 5 | 2017 |
| Cairo University | Academic/Hospital | 13 | 12 | 5 | 2016 |
| Ain Shams University | Academic/Hospital | 12 | 11 | 5 | 2016 |
| Government of Taiwan | Government | 10 | 7 | 2 | 2014 |
| Mansoura University | Academic/Hospital | 10 | 10 | 3 | 2017 |
| Mayo Clinic | Academic/Hospital | 8 | 8 | 3 | 2016 |
| Kaohsiung Medical University | Academic/Hospital | 7 | 7 | 4 | 2017 |
| Bharat Biotech International Limited | For profit | 6 | 6 | 1 | 2012 |
| Government of Spain | Government | 6 | 5 | 2 | 2013 |
| University of Athens | Academic/Hospital | 6 | 6 | 1 | 2019 |
| University of Miami | Academic/Hospital | 6 | 5 | 2 | 2012 |
| Benha University | Academic/Hospital | 5 | 5 | 4 | 2018 |
| Istanbul University | Academic/Hospital | 5 | 5 | 2 | 2020 |
| Sohag University | Academic/Hospital | 5 | 4 | 3 | 2021 |
| Tanta University | Academic/Hospital | 5 | 4 | 3 | 2018 |
| Universidad Autonoma de Nuevo Leon | Academic/Hospital | 5 | 5 | 2 | 2013 |
| University of Bologna | Academic/Hospital | 5 | 5 | 2 | 2013 |
| Zagazig University | Academic/Hospital | 5 | 5 | 2 | 2018 |
| Acibadem University | Academic/Hospital | 4 | 4 | 2 | 2014 |
| Aeon Astron Europe B.V. | For profit | 4 | 0 | 1 | 2016 |