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7-hydroxystaurosporine

Small moleculeexperimental

Clinical trial activity

22 trials · 14 clinical orgs · 0 marketing orgs

Phase 1
16
Phase 2
7
Phase 3
0
Phase 4
0

Earliest trial started Aug 1, 1995 (NCT00001444)

Timeline

1990s

  1. Jan 1, 1995

    Earliest Phase 1 Sponsor(trial)

2000s

  1. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O
Mol. weight
482.54 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 7-hydroxystaurosporine
  • 7-hydroxystaurosporine
  • 7-hydroxystaurosporine
  • 7-hydroxystaurosporine
  • 7-hydroxy-staurosporine
  • (7s)-hydroxyl-staurosporine
  • 8,12-epoxy-1h,8h-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-
  • krx-0601
  • krx-0601
  • kw-2401
  • kw-2401
  • ucn 01
  • ucn-01
  • ucn-01
  • ucn-01
  • ucn-01
  • ucn 02
  • ucn-02
  • ucn-02
  • ucn-02

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT00301938Phase 1Dec 1, 2005National Cancer Institute (NCI), University of Maryland
NCT00098956Phase 2Jan 1, 2005National Cancer Institute (NCI), University of Toronto
NCT00082017Phase 2Apr 5, 2004National Cancer Institute (NCI), National Institutes of Health (NIH)
NCT00072267Phase 2Jan 1, 2004McMaster University, National Cancer Institute (NCI), University of Toronto
NCT00072189Phase 2Nov 1, 2003National Cancer Institute (NCI), University of California, Davis
NCT00030888Phase 2Dec 1, 2002National Cancer Institute (NCI), University of California, San Francisco
NCT00042861Phase 1Aug 1, 2002National Cancer Institute (NCI)
NCT00047242Phase 1Aug 1, 2002Johns Hopkins University, National Cancer Institute (NCI)
NCT00045747Phase 2Jul 1, 2002Cornell University, National Cancer Institute (NCI)
NCT00045513Phase 1/Phase 2 (Phase 2)Jun 1, 2002National Cancer Institute (NCI), University of Toronto
NCT00045175Phase 1Jun 1, 2002McMaster University, National Cancer Institute (NCI), University of Toronto
NCT00045500Phase 1Jun 1, 2002National Cancer Institute (NCI), National Institutes of Health (NIH)
NCT00039403Phase 1Apr 1, 2002National Cancer Institute (NCI), University of Texas at Houston
NCT00036777Phase 1Mar 1, 2002National Cancer Institute (NCI), University of Maryland
NCT00031681Phase 1Dec 1, 2001National Cancer Institute (NCI), University of Virginia, Washington University in St. Louis
NCT00006464Phase 1Mar 1, 2001City of Hope National Medical Center, National Cancer Institute (NCI), University of California, Davis
NCT00012194Phase 1Mar 1, 2001Dartmouth University, National Cancer Institute (NCI)
NCT00004263Phase 1Dec 1, 1999National Cancer Institute (NCI), University of Texas at Houston
NCT00019838Phase 1Jul 1, 1999National Cancer Institute (NCI)
NCT00004059Phase 1Jul 1, 1999Cornell University, National Cancer Institute (NCI)
Showing 20 of 22 trials
Page 1 / 2

Organizations

Research & Development (14)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Cancer Institute (NCI)Government221221995
University of TorontoAcademic/Hospital4322002
Cornell UniversityAcademic/Hospital2221999
Johns Hopkins UniversityAcademic/Hospital2211998
McMaster UniversityAcademic/Hospital2022002
National Institutes of Health (NIH)Government2022002
University of California, DavisAcademic/Hospital2022001
University of MarylandAcademic/Hospital2012002
University of Texas at HoustonAcademic/Hospital2111999
City of Hope National Medical CenterAcademic/Hospital1112001
Dartmouth UniversityAcademic/Hospital1012001
University of California, San FranciscoAcademic/Hospital1112002
University of VirginiaAcademic/Hospital1012001
Washington University in St. LouisAcademic/Hospital1012001
14 organizations
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