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Pituitary ACTH Hypersecretion

A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.

Drugs by status

Approved for this indication (3)

  • osilodrostat
  • pasireotide
  • pergolide

Phase 4 trials (3)

  • liraglutide
  • insulin human
  • sitagliptin

Phase 3 trials (3)

  • mifepristone
  • cabergoline
  • ketoconazole

Phase 2 trials (7)

  • cudc-907
  • roscovitine
  • bexarotene
  • vorinostat
  • gefitinib
  • crn04894
  • lu ag13909

Phase 1 trials (1)

  • vitamin d3

Other trials (4)

  • heparin
  • c11 methionine
  • i-131 iodocholesterol
  • corticorelin ovine triflutate

Organizations

Organization Involved with Phase 4 Indications (1)

  • University of Palermo

Organization Involved with Phase 3 Indications (6)

  • Corcept Therapeutics
  • Cortendo AB
  • National Institutes of Health (NIH)
  • University of London
  • Seth Gordhandas Sunderdas Medical College
  • Barts & The London NHS Trust

Organization Involved with Phase 2 Indications (9)

  • AstraZeneca
  • National Cancer Institute (NCI)
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • Cedars-Sinai Medical Center
  • University of Virginia
  • Fudan University
  • University of California, Los Angeles
  • University of Oxford

Organization Involved with Other Experimental Indications (1)

  • University of Lyon

ICD-10 crosswalk

  • E24.0 — Pituitary-dependent Cushing's disease

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