← Mechanisms of action
PIK3CA
SINGLE PROTEINHomo sapiens
Preferred name: PI3-kinase p110-alpha subunit ChEMBL ↗
Linked proteins
Drugs acting on this target (28)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| cgt6297 | Allosteric antagonist | experimental | Small molecule | PIK3CA allosteric antagonist |
| loxo-783 | Antagonist | experimental | Small molecule | PIK3CA antagonist |
| rly-2608 | Antagonist | experimental | Small molecule | PIK3CA antagonist |
| sl-901 | Antagonist | experimental | Small molecule | PIK3CA antagonist |
| alpelisib (Piqray) | Inhibitor | approved | Small molecule | PIK3CA inhibitor |
| azd8835 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| bay-1082439 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| copanlisib (aliqopa) | Inhibitor | approved | Small molecule | PIK3CA inhibitor |
| cudc-907 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| cyh33 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| etx-636 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| hs-10352 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| inavolisib (Itovebi) | Inhibitor | approved | Small molecule | PI3-kinase p110-alpha subunit inhibitor |
| kanglaite | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| lae005 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| oki-219 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| pki-179 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| pwt-33579 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| rly-5836 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| rp903 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| serabelisib | Inhibitor | experimental | Small molecule | PI3-kinase p110-alpha subunit inhibitor |
| snv4818 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| stx-478 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| tak-117 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| tos-358 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| tq-b3525 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| vt30 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |
| vvd-159642 | Inhibitor | experimental | Small molecule | PIK3CA inhibitor |