Befotertinib
Small moleculeexperimental
Clinical trial activity
12 trials · 14 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
7
Phase 3
2
Phase 4
1
Earliest trial started Jan 3, 2018 (NCT03452150)
Timeline
Indications
Studied for
- Antineoplastic Agents · Phase 2
- Bevacizumab · Phase 2
- Carboplatin · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 3
- Chemotherapy, Adjuvant · Phase 2
- Disease-Free Survival · Phase 4
- Drugs, Investigational · Phase 2
- Epidermal Growth Factor · Phase 2
- Genes, erbB-1 · Phase 3
- Lung Neoplasms · Phase 1
- Mutation · Phase 2/Phase 3
- Neoplasms · Phase 2
- Pemetrexed · Phase 2
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
C=CC(=O)Nc1cc(Nc2nccc(-c3cn(CC(F)(F)F)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C- Mol. weight
- 567.62 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5095167 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07181499 | Phase 2 | Sep 30, 2025 | Betta Pharmaceuticals Co.,Ltd., Jiangmen Central Hospital, Sun Yat-Sen University, The First People's Hospital of Zhaoqing City, Xiamen University |
| NCT06755684 | Phase 2 | Nov 7, 2024 | Huazhong University of Science and Technology |
| NCT06863506 | Phase 2 | Oct 1, 2024 | Sichuan University, Wenzhou Medical University, Zhejiang University, Zhengzhou University |
| NCT06517953 | Phase 2 | Jul 17, 2024 | Sun Yat-Sen University |
| NCT06561620 | Phase 4 | May 1, 2024 | Fudan University |
| NCT06015568 | Phase 1 | Sep 1, 2023 | Betta Pharmaceuticals Co.,Ltd., Jiao Tong University |
| NCT06041776 | Phase 3 | Mar 28, 2023 | Betta Pharmaceuticals Co.,Ltd., Jiao Tong University |
| NCT05007938 | Phase 2 | Aug 12, 2021 | Betta Pharmaceuticals Co.,Ltd., Xiamen University |
| NCT04464551 | Phase 1 | Aug 31, 2020 | Betta Pharmaceuticals Co.,Ltd., Nanjing Medical University |
| NCT04206072 | Phase 2/Phase 3 (Phase 3) | Feb 1, 2020 | Betta Pharmaceuticals Co.,Ltd., Jiao Tong University |
| NCT03861156 | Phase 2 | Feb 22, 2019 | InventisBio Inc., Jiao Tong University |
| NCT03452150 | Phase 1 | Jan 3, 2018 | InventisBio Inc. |
Showing 12 of 12 trials
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Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Betta Pharmaceuticals Co.,Ltd. | For profit | 6 | 6 | 3 | 2020 |
| Jiao Tong University | Academic/Hospital | 4 | 0 | 3 | 2019 |
| InventisBio Inc. | For profit | 2 | 2 | 2 | 2018 |
| Sun Yat-Sen University | Academic/Hospital | 2 | 1 | 1 | 2024 |
| Xiamen University | Academic/Hospital | 2 | 0 | 1 | 2021 |
| Fudan University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Jiangmen Central Hospital | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Nanjing Medical University | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Sichuan University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| The First People's Hospital of Zhaoqing City | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Wenzhou Medical University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Zhengzhou University | Academic/Hospital | 1 | 0 | 1 | 2024 |
14 organizations
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