← Mechanisms of action
KIT
SINGLE PROTEINHomo sapiens
Preferred name: Stem cell growth factor receptor ChEMBL ↗
Linked proteins
Drugs acting on this target (54)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| mgta-117 | Antagonist | experimental | mAb | KIT antagonist |
| amg-191 | Inhibitor | experimental | mAb | KIT inhibitor |
| amuvatinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| anlotinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| avapritinib (Ayvakit) | Inhibitor | approved | Small molecule | Stem cell growth factor receptor inhibitor |
| beam-103 | Inhibitor | experimental | mAb | KIT inhibitor |
| bezuclastinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| blu-263 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| blu-808 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| cdx-0158 | Inhibitor | experimental | mAb | KIT inhibitor |
| cdx-0159 | Inhibitor | experimental | mAb | KIT inhibitor |
| cediranib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| cm-082 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| crenolanib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| dasatinib (sprycel) | Inhibitor | approved | Small molecule | KIT inhibitor |
| dcc-3009 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| enmd 2076 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| famitinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| foretinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| gtx-b001 | Inhibitor | experimental | mAb | KIT inhibitor |
| idrx-42 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| imatinib (gleevec) | Inhibitor | approved | Small molecule | KIT inhibitor |
| jsp191 | Inhibitor | experimental | mAb | KIT inhibitor |
| lop628 | Inhibitor | experimental | mAb | KIT inhibitor |
| masitinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| midostaurin (rydapt) | Inhibitor | approved | Small molecule | KIT inhibitor |
| nb003 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| nn3201 | Inhibitor | experimental | mAb | KIT inhibitor |
| osi-930 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| pazopanib (votrient) | Inhibitor | approved | Small molecule | KIT inhibitor |
| pexidartinib (Turalio) | Inhibitor | approved | Small molecule | KIT inhibitor |
| plx9486 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| quizartinib (VANFLYTA) | Inhibitor | approved | Small molecule | KIT inhibitor |
| regorafenib (stivarga) | Inhibitor | approved | Small molecule | KIT inhibitor |
| ripretinib (Qinlock) | Inhibitor | approved | Small molecule | Stem cell growth factor receptor inhibitor |
| romiplostim (nplate) | Inhibitor | approved | Small molecule | KIT inhibitor |
| Seralutinib | Inhibitor | experimental | Small molecule | Stem cell growth factor receptor inhibitor |
| sitravatinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| sorafenib (nexavar) | Inhibitor | approved | Small molecule | KIT inhibitor |
| stem cell factor | Inhibitor | experimental | Recombinant protein | KIT inhibitor |
| su14813 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| subutinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| sunitinib (sutent) | Inhibitor | approved | Small molecule | KIT inhibitor |
| t-1301 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| tandutinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| telatinib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| telatinib mesylate | Inhibitor | experimental | Small molecule | KIT inhibitor |
| thb001 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| thb335 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| the-630 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| tivozanib (Fotivda) | Inhibitor | approved | Small molecule | Stem cell growth factor receptor inhibitor |
| vatalanib | Inhibitor | experimental | Small molecule | KIT inhibitor |
| xl820 | Inhibitor | experimental | Small molecule | KIT inhibitor |
| xl999 | Inhibitor | experimental | Small molecule | KIT inhibitor |