← Mechanisms of action
TOP2A
SINGLE PROTEINHomo sapiens
Preferred name: DNA topoisomerase II alpha ChEMBL ↗
Linked proteins
Drugs acting on this target (11)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| aclarubicin | Inhibitor | experimental | Small molecule | TOP2A inhibitor |
| aldoxorubicin | Inhibitor | experimental | Small molecule | TOP2A inhibitor |
| amrubicin | Inhibitor | experimental | Small molecule | TOP2A inhibitor |
| daunorubicin (cerubidine) | Inhibitor | approved | Small molecule | TOP2A inhibitor |
| doxorubicin (Doxil) | Inhibitor | approved | Small molecule | TOP2A inhibitor |
| etoposide (vepesid) | Inhibitor | approved | Small molecule | TOP2A inhibitor |
| geh300079 | Inhibitor | experimental | Small molecule | TOP2A inhibitor |
| idarubicin (idamycin) | Inhibitor | approved | Small molecule | TOP2A inhibitor |
| mitoxantrone (novantrone) | Inhibitor | approved | Small molecule | TOP2A inhibitor |
| mm-302 | Inhibitor | experimental | mAb | TOP2A inhibitor |
| valrubicin (valstar) | Inhibitor | approved | Small molecule | TOP2A inhibitor |