neramexane mesylate
Small moleculeexperimental
Clinical trial activity
7 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
6
Phase 3
4
Phase 4
0
Earliest trial started May 1, 2008 (NCT00661440)
Timeline
Indications
Mechanism of action
Neuronal acetylcholine receptor; alpha9/alpha10 antagonist
- Glutamate [NMDA] receptorANTAGONIST
Glutamate [NMDA] receptor antagonist
- Glutamate receptor ionotropic, NMDA 1 (GRIN1) ↗
- Glutamate receptor ionotropic, NMDA 2A (GRIN2A) ↗
- Glutamate receptor ionotropic, NMDA 2B (GRIN2B) ↗
- Glutamate receptor ionotropic, NMDA 2D (GRIN2D) ↗
- Glutamate receptor ionotropic, NMDA 3B (GRIN3B) ↗
- Glutamate receptor ionotropic, NMDA 2C (GRIN2C) ↗
- Glutamate receptor ionotropic, NMDA 3A (GRIN3A) ↗
- Glutamate (NMDA) receptor subunit zeta 1
- Glutamate [NMDA] receptor subunit epsilon 1
- Glutamate [NMDA] receptor subunit epsilon 2
- Glutamate [NMDA] receptor subunit 3A
- Glutamate [NMDA] receptor subunit epsilon 4
- Glutamate [NMDA] receptor subunit epsilon 3
- Glutamate NMDA receptor; GRIN1/GRIN2B
- Glutamate NMDA receptor; GRIN1/GRIN2A
- Ionotropic glutamate receptor NMDA 1/2C
- Ionotropic glutamate receptor NMDA 1/2D
- Glutamate NMDA receptor; GRIN1/GRIN2A/GRIN2B
- Glutamate receptor ionotropic, NMDA 1/2C/3B
Chemistry & pharmacology
Loading structure…
SMILES
CC1(C)CC(C)(C)CC(C)(N)C1.CS(=O)(=O)O- Mol. weight
- 265.42 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2106798 ↗
Also known as
- neramexane mesylate
- neramexane mesylate
- neramexane mesylate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00955799 | Phase 3 | Sep 1, 2009 | Merz |
| NCT00799942 | Phase 2 | May 1, 2009 | Merz |
| NCT00827008 | Phase 3 | Jan 1, 2009 | Merz |
| NCT00772980 | Phase 3 | Nov 1, 2008 | Merz |
| NCT00739635 | Phase 3 | Sep 1, 2008 | Merz |
| NCT00712283 | Phase 1 | Jul 1, 2008 | Merz |
| NCT00661440 | Phase 2 | May 1, 2008 | Merz, University of Leicester |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merz | For profit | 7 | 7 | 3 | 2008 |
| University of Leicester | Academic/Hospital | 1 | 0 | 1 | 2008 |
2 organizations
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