CDEK
← Mechanisms of action

APP

SINGLE PROTEINHomo sapiens
Preferred name: Beta amyloid A4 protein ChEMBL ↗

Linked proteins

Drugs acting on this target (67)

Active Pharmaceutical Ingredient Mechanism Type ▲ Approval Status API Type Mechanism of Action
ion269Antisense inhibitorexperimentalNucleic acidAPP antisense inhibitor
[123i] av-151Binding agentexperimentalSmall moleculeAPP binding agent
123-i mni-187 injection and imaging proceduresBinding agentexperimentalSmall moleculeAPP binding agent
aducanumab (Aduhelm)Binding agentapprovedmAbBeta amyloid A4 protein binding agent
bapineuzumabBinding agentexperimentalmAbBeta amyloid A4 protein binding agent
gantenerumabBinding agentexperimentalmAbBeta amyloid A4 protein binding agent
gsk-933776Binding agentexperimentalmAbBeta amyloid A4 protein binding agent
pittsburgh compound bBinding agentexperimentalSmall moleculeAPP binding agent
ponezumabBinding agentexperimentalmAbBeta amyloid A4 protein binding agent
solanezumabBinding agentexperimentalmAbBeta amyloid A4 protein binding agent
contraloidDegraderexperimentalSmall moleculeAPP degrader
donanemab (Kisunla)Disrupting agentapprovedmAbBeta amyloid A4 protein disrupting agent
aci-24Immunity, activeexperimentalVaccineAPP immunity, active
affitope ad06Immunity, activeexperimentalVaccineAPP immunity, active
an-1792Immunity, activeexperimentalPeptideAPP immunity, active
av-1959Immunity, activeexperimentalVaccineAPP immunity, active
cad106Immunity, activeexperimentalVaccineAPP immunity, active
ub-311Immunity, activeexperimentalVaccineAPP immunity, active
124i-mu 11-1f4Immunity, passiveexperimentalmAbAPP immunity, passive
pf-05236812Immunity, passiveexperimentalmAbAPP immunity, passive
ponezumabImmunity, passiveexperimentalmAbAPP immunity, passive
11-1f4InhibitorexperimentalmAbAPP inhibitor
124i-p5+14 injectionInhibitorexperimentalPeptideAPP inhibitor
aducanumab (Aduhelm)InhibitorapprovedmAbAPP inhibitor
as-s603InhibitorexperimentalSmall moleculeAPP inhibitor
at-02InhibitorexperimentalmAbAPP inhibitor
bapineuzumabInhibitorexperimentalmAbAPP inhibitor
bey2153InhibitorexperimentalSmall moleculeAPP inhibitor
cael-101InhibitorexperimentalmAbAPP inhibitor
cm383InhibitorexperimentalSmall moleculeAPP inhibitor
crenezumabInhibitorexperimentalmAbAPP inhibitor
gantenerumabInhibitorexperimentalmAbAPP inhibitor
gsk-933776InhibitorexperimentalmAbAPP inhibitor
gsk2398852InhibitorexperimentalmAbAPP inhibitor
homotaurineInhibitorexperimentalSmall moleculeAPP inhibitor
jbpos0101InhibitorexperimentalSmall moleculeAPP inhibitor
latrepirdineInhibitorexperimentalSmall moleculeAPP inhibitor
LECANEMAB (Leqembi)InhibitorapprovedmAbAPP inhibitor
ly2599666InhibitorexperimentalmAbAPP inhibitor
medi1814InhibitorexperimentalmAbAPP inhibitor
mni-330InhibitorexperimentalSmall moleculeAPP inhibitor
neod001InhibitorexperimentalmAbAPP inhibitor
ngp 555InhibitorexperimentalSmall moleculeAPP inhibitor
ni006InhibitorexperimentalmAbAPP inhibitor
npt088InhibitorexperimentalSmall moleculeAPP inhibitor
p16-129InhibitorexperimentalSmall moleculeAPP inhibitor
ppi-1019InhibitorexperimentalPeptideAPP inhibitor
prm-151InhibitorexperimentalRecombinant proteinAPP inhibitor
prx004InhibitorexperimentalmAbAPP inhibitor
RemternetugInhibitorexperimentalmAbAPP inhibitor
rn6gInhibitorexperimentalmAbAPP inhibitor
sar228810InhibitorexperimentalmAbAPP inhibitor
shr-1707InhibitorexperimentalSmall moleculeAPP inhibitor
solanezumabInhibitorexperimentalmAbAPP inhibitor
tramiprosateInhibitorexperimentalSmall moleculeAPP inhibitor
v950InhibitorexperimentalSmall moleculeAPP inhibitor
vanutide cridificarInhibitorexperimentalBiologicalAPP inhibitor
vp 20629InhibitorexperimentalSmall moleculeAPP inhibitor
aducanumab (Aduhelm)OtherapprovedmAbAPP other
bapineuzumabOtherexperimentalmAbAPP other
gantenerumabOtherexperimentalmAbAPP other
gsk-933776OtherexperimentalmAbAPP other
ponezumabOtherexperimentalmAbAPP other
solanezumabOtherexperimentalmAbAPP other
tramiprosateStabiliserexperimentalSmall moleculeBeta amyloid A4 protein stabiliser
ValiltramiprosateStabiliserexperimentalSmall moleculeBeta amyloid A4 protein stabiliser
vanutide cridificarVaccine antigenexperimentalBiologicalBeta amyloid A4 protein vaccine antigen