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pittsburgh compound b

Small moleculeexperimentalImaging agent

Pittsburgh compound B (PiB) is a radioactive analog of thioflavin T, which can be used in positron emission tomography scans to image beta-amyloid plaques in neuronal tissue. Due to this property, Pittsburgh compound B may be used in investigational studies of Alzheimer's disease. — Wikipedia

Clinical trial activity

24 trials · 21 clinical orgs · 0 marketing orgs

Phase 1
12
Phase 2
10
Phase 3
4
Phase 4
1

Earliest trial started Apr 1, 2008 (NCT00950430)

Timeline

2010s

  1. Jan 1, 2010

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2012

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2014

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

[11CH3]Nc1ccc(-c2nc3ccc(O)cc3s2)cc1
Mol. weight
255.33 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Imaging
11-carbon

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • (11c)6-oh-bta-1
  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • 6-oh-bta-1
  • c-11 pib
  • c11 pib
  • n-methyl-(11c)2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • pittsburgh compound b
  • pittsburgh compound b
  • pittsburgh compound b

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06999434Phase 1May 5, 2025National Institute on Aging (NIA), National Institutes of Health (NIH), Yale University
NCT05805839Phase 2Jul 10, 2023Mayo Clinic
NCT05361382Phase 1Nov 23, 2021National Institute on Aging (NIA), University of Pittsburgh
NCT04542603Phase 1Aug 31, 2021University of Alabama, Birmingham
NCT04604587Phase 3Oct 8, 2020National Taiwan University
NCT04604600Phase 3Sep 3, 2020National Taiwan University
NCT04364672Phase 1Jul 1, 2020University of Alabama, Birmingham
NCT04768101Early Phase 1 (Phase 1)Apr 15, 2020Vanderbilt University
NCT04263337Phase 1Mar 12, 2020Harvard University, Medical College of Wisconsin, University of North Carolina at Chapel Hill
NCT04134923Phase 2Oct 7, 2019Washington University in St. Louis
NCT03757910Early Phase 1 (Phase 1)Jul 31, 2019Columbia University, George Washington University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Yeshiva University
NCT03958630Phase 1Jul 5, 2019National Institute of Mental Health (NIMH)
NCT03981380Phase 2Jun 30, 2019Columbia University, National Institute on Aging (NIA), Wake Forest University
NCT03746366Early Phase 1 (Phase 1)Dec 1, 2018National Institute on Alcohol Abuse and Alcoholism (NIAAA), University of Pittsburgh
NCT03969732Phase 3Sep 27, 2018National Taiwan University
NCT03503331Phase 2Apr 20, 2018University of Alabama, Birmingham
NCT03555292Phase 2Jul 12, 2017Oriental Neurosurgery Evidence-Based-Study Team, Tianjin Medical University
NCT02740634N/AMay 1, 2016Mayo Clinic
NCT03542656Phase 3Sep 11, 2014National Taiwan University
NCT01723553Phase 1Nov 1, 2012Mayo Clinic
Showing 20 of 24 trials
Page 1 / 2

Organizations

Research & Development (21)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Mayo ClinicAcademic/Hospital7742008
National Institute on Aging (NIA)Government4032008
National Taiwan UniversityAcademic/Hospital4412014
University of Alabama, BirminghamAcademic/Hospital3322018
Columbia UniversityAcademic/Hospital2222019
University of PittsburghAcademic/Hospital2212018
George Washington UniversityAcademic/Hospital1012019
Harvard UniversityAcademic/Hospital1012020
Medical College of WisconsinAcademic/Hospital1012020
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government1012019
National Institute of Mental Health (NIMH)Government1112019
National Institute on Alcohol Abuse and Alcoholism (NIAAA)Government1012018
National Institutes of Health (NIH)Government1012025
Oriental Neurosurgery Evidence-Based-Study TeamAcademic/Hospital1112017
Tianjin Medical UniversityAcademic/Hospital1012017
University of North Carolina at Chapel HillAcademic/Hospital1112020
Vanderbilt UniversityAcademic/Hospital1112020
Wake Forest UniversityAcademic/Hospital1012019
Washington University in St. LouisAcademic/Hospital1112019
Yale UniversityAcademic/Hospital1112025
21 organizations
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