cd45-depleted allogenic peripheral blood stem cell
Cell therapyexperimental
Clinical trial activity
10 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
8
Phase 3
1
Phase 4
0
Earliest trial started Aug 1, 2014 (NCT02337595)
Timeline
Indications
Studied for
- Anemia, Aplastic · Phase 2
- Anemia, Diamond-Blackfan · Phase 1/Phase 2
- Anemia, Sickle Cell · Phase 1/Phase 2
- beta-Thalassemia · Phase 1/Phase 2
- Bone Marrow Failure Disorders · Phase 2
- Graft vs Host Disease · Phase 2/Phase 3
- Hematologic Neoplasms · Phase 1/Phase 2
- Hematopoietic Stem Cell Transplantation · Phase 1
- Hodgkin Disease · Phase 2
- Immune System Diseases · Phase 1/Phase 2
- Leukemia · Phase 2/Phase 3
- Leukemia, Biphenotypic, Acute · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 2
- Leukemia, Myeloid, Acute · Phase 2
- Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative · Phase 2
- Leukemia, Myeloid, Chronic-Phase · Phase 2
- Leukemia, Myelomonocytic, Juvenile · Phase 2
- Lymphoma · Phase 2/Phase 3
- Lymphoma, Non-Hodgkin · Phase 2
- Myelodysplastic Syndromes · Phase 2/Phase 3
- Myeloproliferative Disorders · Phase 2
- Neoplasms · Phase 2
- Opportunistic Infections · Phase 2/Phase 3
- Plasmacytoma · Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 2
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 2
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1/Phase 2
- Primary Immunodeficiency Diseases · Phase 2
- Sarcoma, Myeloid · Phase 2
Mechanism of action
- leukocytesTissue restoration
leukocytes tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- cd45-depleted allogenic peripheral blood stem cell
- cd45ra-depleted hpc
- cd45ra-depleted peripheral blood mononuclear cells
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05943067 | Phase 1/Phase 2 (Phase 2) | Apr 27, 2023 | University of Tuebingen |
| NCT05066412 | Phase 1 | Oct 15, 2021 | University of Geneva |
| NCT04558736 | Phase 2 | Nov 30, 2020 | St. Jude Children's Hospital |
| NCT03970096 | Phase 2 | Jul 6, 2019 | National Cancer Institute (NCI), University of Washington |
| NCT03849651 | Phase 2 | Jan 31, 2019 | St. Jude Children's Hospital |
| NCT03653338 | Phase 1/Phase 2 (Phase 2) | Sep 30, 2018 | University of Pittsburgh |
| NCT02942173 | Phase 2/Phase 3 (Phase 3) | Oct 1, 2016 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology |
| NCT02737384 | Phase 2 | May 1, 2016 | University of Paris |
| NCT02259348 | Phase 2 | Oct 1, 2014 | St. Jude Children's Hospital |
| NCT02337595 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2014 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology |
Showing 10 of 10 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| St. Jude Children's Hospital | Academic/Hospital | 3 | 3 | 1 | 2014 |
| Federal Research Institute of Pediatric Hematology, Oncology and Immunology | Government | 2 | 2 | 2 | 2014 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2019 |
| University of Geneva | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Paris | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Pittsburgh | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Tuebingen | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Washington | Academic/Hospital | 1 | 1 | 1 | 2019 |
8 organizations
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