urokinase
Trade name: kinlytic
Approved
Jan 16, 1978
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and Pilling in 1947. Urokinase was originally isolated from human urine, and it is also present in the blood and in the extracellular matrix of many tissues. The primary physiological substrate of this enzyme is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolytic cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This cascade had been involved in vascular diseases and cancer progression. — Wikipedia
Clinical trial activity
23 trials · 26 clinical orgs · 1 marketing orgs
Earliest trial started Feb 1, 2002 (NCT00537498)
Timeline
1970s
- Jan 16, 1978
Microbix Biosystems — Earliest FDA Approval
- Jan 16, 1978
Microbix Biosystems — NDA Secondary Org
- Jan 16, 1978
Microbix Biosystems — NDA Organization
Indications
Approved for
Studied for
- Arterial Occlusive Diseases · Phase 3
- Chronic Limb-Threatening Ischemia · Phase 3
- Coronary Artery Disease · Phase 4
- Diabetic Foot · Phase 3
- Empyema · Phase 3
- Empyema, Pleural · Phase 4
- Hemothorax · Phase 3
- Infections · Phase 3
- Ischemia · Phase 3
- Ischemic Stroke · Phase 3
- Peripheral Arterial Disease · Phase 2
- Pleural Diseases · Phase 4
- Pleural Effusion · Phase 4
- Pneumonia · Phase 3
- Pulmonary Embolism · Phase 4
- Stroke · Phase 3
- Thromboembolism · Phase 4
- Thrombosis · Phase 3
Mechanism of action
- PlasminogenACTIVATOR
PLG activator
- Urokinase-type plasminogen activatorEXOGENOUS PROTEIN
Urokinase-type plasminogen activator exogenous protein
- Urokinase-type plasminogen activatorSupplementation
PLAU supplementation
Approval history
- approvedJan 16, 1978
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
- Multi-specific
- No
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaUrokinase ↗
- NCATS83G67E21XI ↗
- ChEMBLCHEMBL1201420 ↗
Also known as
- abbokinase
- abbokinase
- kinlytic
- kinlytic
- kinlytic
- ukidan
- upa
- upa
- u-plasminogen activator
- urokinase
- urokinase
- urokinase
- urokinase
- urokinase
- urokinase
- urokinase
- urokinase
- urokinase
- urokinase
- urokinase-type plasminogen activator precursor
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07047326 | N/A | Oct 1, 2025 | Capital Medical University |
| NCT05700591 | Phase 3 | Jan 29, 2023 | Tasly Pharmaceuticals, Inc. |
| NCT05507645 | Phase 3 | Oct 21, 2022 | Capital Medical University |
| NCT04420351 | Phase 3 | Jun 10, 2020 | Capital Medical University, Huazhong University of Science and Technology, People's Liberation Army of China, Zhengzhou University |
| NCT03716375 | N/A | Nov 30, 2018 | Capital Medical University |
| NCT03578822 | Phase 3 | Jul 31, 2018 | Tasly Pharmaceuticals, Inc. |
| NCT03541668 | Phase 3 | May 18, 2018 | Tasly Pharmaceuticals, Inc. |
| NCT02036255 | Phase 3 | May 1, 2015 | Free University of Brussels |
| NCT02165891 | Phase 3 | Feb 1, 2015 | Free University of Brussels |
| NCT02414802 | N/A | Dec 1, 2014 | Xuzhou Medical University |
| NCT01568931 | Phase 4 | Jan 1, 2014 | University of Roma La Sapienza |
| NCT01638585 | Phase 3 | Jun 1, 2011 | GWT-TUD GmbH |
| NCT01222117 | Phase 2 | Dec 1, 2010 | Grifols |
| NCT01134237 | Phase 3 | May 1, 2010 | National Taiwan University |
| NCT01108120 | Phase 2 | May 1, 2010 | People's Liberation Army of China |
| NCT00798278 | Phase 3 | Jul 1, 2008 | Spanish Society of Pediatric Surgery |
| NCT00823225 | Phase 3 | Jun 1, 2008 | Medac, Technical University of Dresden |
| NCT00502632 | Phase 2/Phase 3 (Phase 3) | Oct 1, 2007 | Roche, University of Adelaide, University of Padova |
| NCT00968929 | Phase 4 | Jun 1, 2006 | Capital Medical University, Guangzhou Medical University, Ningxia Medical University, People's Liberation Army of China, Qingdao University, Shanxi Medical University, Shenzhen University, Tianjin Medical University |
| NCT00144950 | Phase 1 | Sep 2, 2005 | National Institutes of Health (NIH), University of London |
Organizations
Research & Development (26)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Capital Medical University | Academic/Hospital | 6 | 5 | 3 | 2002 |
| People's Liberation Army of China | Government | 3 | 1 | 3 | 2006 |
| Tasly Pharmaceuticals, Inc. | For profit | 3 | 3 | 1 | 2018 |
| Free University of Brussels | Academic/Hospital | 2 | 2 | 1 | 2015 |
| Medac | For profit | 2 | 2 | 2 | 2002 |
| Grifols | For profit | 1 | 1 | 1 | 2010 |
| Guangzhou Medical University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| GWT-TUD GmbH | For profit | 1 | 1 | 1 | 2011 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 0 | 1 | 2020 |
| National Institutes of Health (NIH) | Government | 1 | 1 | 1 | 2005 |
| National Taiwan University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Ningxia Medical University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Qingdao University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Roche | For profit | 1 | 0 | 1 | 2007 |
| Shanxi Medical University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Shenzhen University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Spanish Society of Pediatric Surgery | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Technical University of Dresden | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Tianjin Medical University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Universidad Autonoma de Barcelona | Academic/Hospital | 1 | 1 | 1 | 2003 |
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Microbix Biosystems | For profit | NDA2 | Jan 16, 1978 |
| Microbix Biosystems | For profit | NDA | Jan 16, 1978 |