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resveratrol

Small moleculeexperimental

Resveratrol, a natural non-flavonoid polyphenol, exhibits a wide range of beneficial properties as an anticancer agent, a platelet anti-aggregation agent, and an antioxidant, as well as its anti-aging, anti-inflammatory, antiallergenic. This compound is in phase III clinical trials in combination with carboxymethyl-β-glucan for improving nasal symptoms in children with pollen-induced allergic rhinitis. Also in phase III clinical trial in the treatment of painful knee osteoarthritis and in type 2 diabetic patients. It has been demonstrated that resveratrol may prevent type 2 diabetic by targeting Sirtuin type 1 (SIRT1), indicating that SIRT1 may be a novel therapeutic target for diabetes prevention. — NCATS

Clinical trial activity

161 trials · 166 clinical orgs · 0 marketing orgs

Phase 1
32
Phase 2
52
Phase 3
20
Phase 4
7

Earliest trial started May 4, 2004 (NCT03091543)

Timeline

2000s

  1. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1
Mol. weight
228.2433 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 3,4',5-stilbenetriol
  • 3,4',5-trihydroxystilbene
  • 3,4',5-trihydroxystilbene
  • 3,4',5-trihydroxy-trans-stilbene
  • 3,4',5-trihydroxy-trans-stilbene
  • 3,5,4'-trihydroxystilbene
  • 3,5,4'-trihydroxystilbene
  • 3,5,4'-trihydroxystilbene
  • 5-[(e)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol
  • 5-[(e)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol
  • cis-resveratrol
  • (e)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol(e)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
  • (e)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol(e)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
  • (e)-resveratrol
  • (e)-resveratrol
  • resveratrol
  • resveratrol
  • resveratrol
  • resveratrol
  • resveratrol-3-sulfate
  • srt501
  • srt501
  • srt501
  • srt501
  • srt 501
  • srt-501
  • trans-resveratrol
  • trans-resveratrol
  • trans-resveratrol
  • trans-resveratrol
  • trans- resveratrol
  • trans- resveratrol
  • trans-resveratrol-3-o-sulfate

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07089381N/AAug 1, 2025Ain Shams University
NCT07060157N/AJul 22, 2025Assiut University
NCT06585865N/AFeb 28, 2025National Strength and Conditioning Association, Texas Tech University
NCT06882564Phase 3Jan 5, 2025Al-Mustansiriyah University
NCT06723119N/AOct 1, 2024Gencor, University of Central Florida
NCT06235294N/ASep 30, 2024University of Coimbra
NCT06470061Phase 2Jul 31, 2024Northwestern University, Zaparackas and Knepper LTD
NCT06521333N/AMay 14, 2024Cairo University
NCT06250283N/AFeb 2, 2024National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH), University of Delaware
NCT06914934N/AFeb 1, 2024Government of Russia, Solvay
NCT07182370N/AJan 15, 2024Government of Spain, Universidad de Murcia
NCT06020313N/AAug 31, 2023University of Pernambuco
NCT05808387N/AMar 6, 2023University of Sao Paulo
NCT05377242N/AJan 31, 2023Department of Defense, University of Alabama, Birmingham
NCT06131918Phase 2Jan 9, 2023Khyber Medical University Peshawar, Khyber Medical University Peshawer
NCT05874882Early Phase 1 (Phase 1)Dec 12, 2022University of Baghdad
NCT05653895N/ADec 7, 2022Khyber Medical University Peshawar, Khyber Medical University Peshawer
NCT05500742N/AAug 31, 2022University of Bologna
NCT05761327N/AJun 3, 2022Ardahan University
NCT05410093N/AFeb 1, 2022Nantong University
Showing 20 of 161 trials
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Organizations

Research & Development (166)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
DSMFor profit12122009
Northumbria UniversityAcademic/Hospital9922008
BialFor profit7712004
Maastricht UniversityAcademic/Hospital7722009
Aarhus UniversityAcademic/Hospital5512010
Government of DenmarkGovernment5012010
National Cancer Institute (NCI)Government5422004
National Institute on Aging (NIA)Government5232012
National Heart, Lung, and Blood Institute (NHLBI)Government4022013
Evolva SAFor profit3012016
Khyber Medical University PeshawarAcademic/Hospital3322021
Northwestern UniversityAcademic/Hospital3232015
University of FloridaAcademic/Hospital3322009
University of ManitobaAcademic/Hospital3322014
University of ParisAcademic/Hospital3222015
American Heart AssociationAcademic/Hospital2022018
Augusta UniversityAcademic/Hospital2222018
Boston UniversityAcademic/Hospital2212010
Department of Veteran AffairsGovernment2222008
Diabetes FondsAcademic/Hospital2012014
166 organizations
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