nitrogen

Small moleculeapproved

Approved

Jun 23, 2013

Elemental nitrogen is a colorless, odorless, tasteless and mostly inert diatomic gas at standard conditions, constituting 78% by volume of Earth's atmosphere. Nitrogen occurs in all living organisms. It is a constituent element of amino acids and therefore of proteins and nucleic acids (DNA and RNA). Nitrogen is found in the chemical structure of almost all neurotransmitters and is a key component of alkaloids. Specific bacteria (e. g. Rhizobium trifolium) possess nitrogenase enzymes which can fix atmospheric nitrogen into a form (ammonium ion) which is chemically useful to higher organisms. Animals use nitrogen-containing amino acids from plant sources, as starting materials for all nitrogen-compound animal biochemistry, including the manufacture of proteins and nucleic acids. Animal metabolism of NO (nitric oxide) results in production of nitrite. Animal metabolism of nitrogen in proteins generally results in excretion of urea, while animal metabolism of nucleic acids results in excretion of urea and uric acid. The characteristic odor of animal flesh decay is caused by nitrogen-containing long-chain amines, such as putrescine and cadaverine. Decay of organisms and their waste products may produce small amounts of nitrate, but most decay eventually returns nitrogen content to the atmosphere, as molecular nitrogen. The circulation of nitrogen from the atmosphere through organics and then back to the atmosphere is commonly referred to as the nitrogen cycle. Nitrogen can be measured in urine with the Kjeldahl method or by spectrophotometric methods (enzymic tests). Total urinary nitrogen is calculated based on urea urinary nitrogen quantified with these methods. Liquid nitrogen (E941) is widely used in food industry as a freezing agent and as a protection against the impact of microorganisms. Nitrogen (E941) extends the period of validity of food and maintains its nutrients and is also used for packing products. In other fields of industry, nitrogen (E941) is useful in suppressing the combustion processes and in creating protective environment in order to avoid oxidation. Medical nitrogen has various medical uses, especially in liquid form when it provides temperatures as low as -196° C. Applications of medical nitrogen in the healthcare environment may include the following: * In cryopreservation for the long-term preservation of blood, blood components, other cells, body fluids or tissue samples. * In cryosurgery for minor surgical procedures in dermatology. * As a component in many gas mixtures. * As a displacement medium for sterile equipment, a non-oxidising displacement medium in pharmaceutical vials and as a propellant in pressurised aerosol dispensers. * As a source of pneumatic pressure to power gas-operated medical devices. * As a coolant for carbon dioxide surgical lasers. — NCATS

Clinical trial activity

35 trials · 44 clinical orgs · 12 marketing orgs

Phase 1
5
Phase 2
18
Phase 3
5
Phase 4
4

Earliest trial started Nov 1, 1998 (NCT00781352)

Timeline

1950s

  1. Jun 1, 1950

    Evidence of US Marketing

1990s

  1. Jan 1, 1998

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jun 23, 2013

    Air Liquide — Earliest FDA Approval

  2. Jun 23, 2013

    Air Liquide — NDA Secondary Org

  3. Jun 23, 2013

    Air Liquide — NDA Organization

  4. Jul 5, 2013

    Linde AG — NDA Secondary Org

  5. Jul 5, 2013

    BOC International — NDA Secondary Org

  6. Jul 14, 2013

    Norco — NDA Secondary Org

  7. Jul 16, 2013

    Airgas Usa Llc — NDA Secondary Org

  8. Jul 21, 2013

    Praxair — NDA Secondary Org

  9. Jul 23, 2013

    Air Products And Chemicals Inc — NDA Secondary Org

  10. Jul 23, 2013

    Aspen Air — NDA Secondary Org

  11. Aug 2, 2013

    Matheson Tri-Gas Inc — NDA Secondary Org

  12. Aug 24, 2018

    Universal Industrial Gases, Inc — NDA Secondary Org

  13. Sep 10, 2018

    Cristal Therapeutics — NDA Secondary Org

2020s

  1. Jun 29, 2020

    Air Liquide — Marketing Organization

  2. Jun 10, 2022

    ABSOLUTE AIR, LLC — Marketing Organization

  3. Jun 10, 2022

    ABSOLUTE AIR, LLC — NDA Secondary Org

Indications

Mechanism of action

  • Unspecified targetRadiopharmaceutical

    radiopharmaceutical

Approval history

  • approvedJun 23, 2013
  • approvedJun 1, 1950

Chemistry & pharmacology

Loading structure…

SMILES

N#N
Mol. weight
28.0134 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Topical
Availability
Prescription Only

Oral

No

Parenteral

No

Topical

Yes

Sources

Also known as

  • e941
  • e941
  • molecular nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen
  • nitrogen gas
  • nitrogen, nf

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07263399N/AJan 31, 2026Blekinge Institute of Technology, Karolinska Institute, Lund University, University of Gothenburg
NCT05873335N/AFeb 28, 2023Gabi SmartCare, University of California, San Francisco
NCT04528771Phase 1Oct 31, 2020Case Western Reserve University
NCT04378426Phase 2Sep 1, 2020Department of Veteran Affairs
NCT04398290Phase 2Jul 1, 2020Bellerophon Therapeutics, University of Miami
NCT04134754N/AOct 31, 2019University of Iowa
NCT03826693Phase 2Sep 30, 2019Brain & Behavior Research Foundation, Stanford University
NCT03978338N/AJul 31, 2019Chinese Academy of Medical Sciences, Zhitong Biopharma CO.,LTD
NCT04022161Phase 2Jul 25, 2019Harvard University, Moorgreen Hospital, Southampton
NCT03748446Early Phase 1 (Phase 1)Dec 15, 2018Harvard University
NCT03331445Phase 2Oct 24, 2017Albert Einstein Israelite Hospital, Mallinckrodt, Nitric Solutions Inc.
NCT03079102Phase 2Jul 1, 2017Mallinckrodt, University of Pittsburgh
NCT02860975Phase 1Jan 1, 2017Harvard University
NCT02572557N/ADec 1, 2016University of Groningen
NCT01891500Phase 4May 1, 2016Mallinckrodt, University of Florida
NCT01939301Phase 2Oct 1, 2013Indiana University, Mallinckrodt, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), The University of Texas, Dallas, University of Mississippi
NCT01925482N/ASep 1, 2013National Institute on Deafness and Other Communication Disorders (NIDCD), University of Pittsburgh
NCT01802619Phase 1/Phase 2 (Phase 2)Aug 31, 2013Xijing Hospital
NCT01692821Phase 4Jun 1, 2012University of Vienna
NCT01220687N/AApr 1, 2011Mallinckrodt, University of Oklahoma
Showing 20 of 35 trials
Page 1 / 2

Organizations

Research & Development (44)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
MallinckrodtFor profit11542002
Air LiquideFor profit4432007
Harvard UniversityAcademic/Hospital3322017
National Heart, Lung, and Blood Institute (NHLBI)Government2012007
University of PittsburghAcademic/Hospital2222013
University of ViennaAcademic/Hospital2121998
Aarhus UniversityAcademic/Hospital1112009
Albert Einstein Israelite HospitalAcademic/Hospital1012017
Bellerophon TherapeuticsFor profit1012020
Blekinge Institute of TechnologyAcademic/Hospital1112026
Brain & Behavior Research FoundationAcademic/Hospital1012019
Case Western Reserve UniversityAcademic/Hospital1112020
Chinese Academy of Medical SciencesAcademic/Hospital1112019
Department of Veteran AffairsGovernment1112020
Foundation for Anesthesia Education and ResearchAcademic/Hospital1012009
Gabi SmartCareAcademic/Hospital1112023
Indiana UniversityAcademic/Hospital1112013
Karolinska InstituteAcademic/Hospital1012026
Lund UniversityAcademic/Hospital1012026
Moorgreen Hospital, SouthamptonAcademic/Hospital1012019
44 organizations
Page 1 / 3

Marketing (19)

OrganizationOrg typeRelationshipDate
ABSOLUTE AIR, LLCFor profitMKTGJun 10, 2022
ABSOLUTE AIR, LLCFor profitNDA2Jun 10, 2022
Air LiquideFor profitSYNJul 13, 2013
Air LiquideFor profitNDA2Jun 23, 2013
Air LiquideFor profitMKTGJun 29, 2020
Air LiquideFor profitNDAJun 23, 2013
Air Products And Chemicals IncFor profitNDA2Jul 23, 2013
Airgas Usa LlcFor profitNDA2Jul 16, 2013
Airgas Usa LlcFor profitSYNSep 7, 2013
Aspen AirFor profitNDA2Jul 23, 2013
BOC InternationalFor profitNDA2Jul 5, 2013
Cristal TherapeuticsFor profitNDA2Sep 10, 2018
Linde AGFor profitSYNJul 5, 2013
Linde AGFor profitNDA2Jul 5, 2013
Matheson Tri-Gas IncFor profitNDA2Aug 2, 2013
NorcoFor profitNDA2Jul 14, 2013
PraxairFor profitSYNAug 27, 2013
PraxairFor profitNDA2Jul 21, 2013
Universal Industrial Gases, IncFor profitNDA2Aug 24, 2018