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cilengitide

Peptideexperimental

Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis, and other aspects of tumor biology. Hence, it is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation. — Wikipedia

Clinical trial activity

30 trials · 26 clinical orgs · 0 marketing orgs

Phase 1
16
Phase 2
17
Phase 3
1
Phase 4
0

Earliest trial started Dec 1, 1999 (NCT00004258)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

2000s

  1. Jan 1, 2004

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(=O)N1C
Mol. weight
588.67 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Multi-specific
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • cilengitide
  • cilengitide
  • cilengitide
  • cilengitide
  • cyclic-arg-gly-asp-d-phe(n-methyl)val
  • cyclo(arginyl-glycyl-formylaspartyl-n-methylvalyl)
  • cyclo(rgdf-n(me)v)
  • emd-12192
  • emd-12192
  • emd121974
  • emd 121974
  • emd 121974
  • emd 121974
  • emd-121974
  • emd-121974
  • emd-121974

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT01782976Phase 2Jun 1, 2013Brain Tumor Trials Collaborative, Merck Serono, University of Texas at Houston
NCT01558687Phase 1Aug 1, 2012Merck KGaA
NCT01517776Phase 2Jan 1, 2012Martin Luther University, Merck KGaA
NCT01504165Phase 1Jan 1, 2012Merck KGaA, Merck Serono
NCT01276496Phase 1Dec 1, 2010Mayo Clinic, National Cancer Institute (NCI)
NCT01165333Phase 1Aug 1, 2010University of Lille
NCT00979862Phase 1Mar 1, 2010National Cancer Institute (NCI)
NCT01118676Phase 1Mar 1, 2010Merck KGaA, University of Toulouse
NCT01122888Phase 1Dec 1, 2009National Cancer Institute (NCI), University of Chicago
NCT01124240Phase 2Nov 1, 2009Merck KGaA, Northern Sydney and Central Coast Area Health Service
NCT01044225Phase 2Sep 1, 2009Free University of Brussels, Universitair Ziekenhuis Brussel
NCT00813943Phase 2Mar 1, 2009Merck KGaA, Merck Serono, University of Alabama, Birmingham
NCT00842712Phase 2Feb 1, 2009Merck KGaA
NCT00884598Phase 1Dec 1, 2008University of Heidelberg, University of Mannheim
NCT00705016Phase 1/Phase 2 (Phase 2)Oct 1, 2008Merck KGaA, University of Antwerp
NCT00689221Phase 3Sep 1, 2008European Organisation for Research and Treatment of Cancer, Merck KGaA, Merck Serono, University of Lausanne
NCT00679354Phase 2Jun 1, 2008National Cancer Institute (NCI)
NCT00085254Phase 1/Phase 2 (Phase 2)Apr 1, 2005National Cancer Institute (NCI)
NCT00112866Phase 2Jan 1, 2005National Cancer Institute (NCI)
NCT00121238Phase 2Jan 1, 2005National Cancer Institute (NCI), University of Michigan
Showing 20 of 30 trials
Page 1 / 2

Organizations

Research & Development (26)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Cancer Institute (NCI)Government161521999
Merck KGaAFor profit9432008
Merck SeronoFor profit5332004
University of Texas at HoustonAcademic/Hospital3112004
University of Alabama, BirminghamAcademic/Hospital2012000
University of ChicagoAcademic/Hospital2012003
University of MichiganAcademic/Hospital2012005
Brain Tumor Trials CollaborativeAcademic/Hospital1012013
Duke UniversityAcademic/Hospital1012004
European Organisation for Research and Treatment of CancerAcademic/Hospital1012008
Free University of BrusselsAcademic/Hospital1012009
HonorHealth Research InstituteAcademic/Hospital1011999
Indiana UniversityAcademic/Hospital1111999
Martin Luther UniversityAcademic/Hospital1112012
Mayo ClinicAcademic/Hospital1012010
Northern Sydney and Central Coast Area Health ServiceAcademic/Hospital1112009
Pediatric Brain Tumor ConsortiumAcademic/Hospital1012003
Universitair Ziekenhuis BrusselAcademic/Hospital1112009
University of AntwerpAcademic/Hospital1012008
University of California, San FranciscoAcademic/Hospital1012000
26 organizations
Page 1 / 2