pamiparib
Small moleculeexperimental
Clinical trial activity
32 trials · 35 clinical orgs · 0 marketing orgs
Phase 1
14
Phase 2
22
Phase 3
3
Phase 4
0
Earliest trial started Jul 1, 2014 (NCT02361723)
Timeline
Indications
Studied for
- Biliary Tract Neoplasms · Phase 2
- Brain Neoplasms · Phase 1/Phase 2
- Breast Neoplasms · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Carcinoma, Ovarian Epithelial · Phase 2
- Carcinoma, Renal Cell · Phase 2
- Carcinosarcoma · Phase 2
- Fallopian Tube Neoplasms · Phase 1/Phase 2
- Glioblastoma · Phase 1/Phase 2
- Glioma · Phase 1/Phase 2
- Hamartoma · Phase 1/Phase 2
- Head and Neck Neoplasms · Phase 1
- Homologous Recombination · Phase 2
- Lymphoma · Phase 3
- Mutation · Phase 1/Phase 2
- Neoadjuvant Therapy · Phase 2
- Neoplasms · Phase 2
- Ovarian Neoplasms · Phase 3
- Prostatic Neoplasms, Castration-Resistant · Phase 2
- Small Cell Lung Carcinoma · Phase 2
- Squamous Cell Carcinoma of Head and Neck · Phase 1
- Stomach Neoplasms · Phase 3
- Triple Negative Breast Neoplasms · Phase 1
Mechanism of action
- Poly [ADP-ribose] polymerase 2INHIBITOR
Poly [ADP-ribose] polymerase 2 inhibitor
- Poly [ADP-ribose] polymerase-1INHIBITOR
Poly [ADP-ribose] polymerase-1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C[C@]12CCCN1CC1=NNC(=O)c3cc(F)cc4[nH]c2c1c34- Mol. weight
- 298.32 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4112930 ↗
Also known as
- bgb-290
- bgb-290
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06692491 | Phase 2 | Jan 1, 2025 | Peking University |
| NCT06387056 | Phase 2 | Apr 1, 2024 | Xiamen University |
| NCT05669768 | Phase 2 | Jan 1, 2023 | Sun Yat-Sen University |
| NCT05573373 | Phase 1 | Dec 20, 2022 | Jiangnan University |
| NCT05652283 | Phase 2 | Nov 6, 2022 | Anhui Medical University |
| NCT05526924 | Phase 1 | Nov 1, 2022 | University of Chicago |
| NCT05489926 | Phase 2 | Aug 16, 2022 | Chinese Academy of Medical Sciences |
| NCT05494580 | Phase 1/Phase 2 (Phase 2) | Aug 10, 2022 | Sun Yat-Sen University, University of Washington |
| NCT05483543 | Phase 2 | Jun 20, 2022 | Fudan University |
| NCT05327621 | Phase 2 | May 1, 2022 | Sun Yat-Sen University |
| NCT05376722 | Phase 2 | Feb 22, 2022 | Nanjing Medical University, Nanjing University, Soochow University, Zhejiang University |
| NCT05044871 | Phase 2 | Jan 1, 2022 | Anhui Medical University, Central South University, Chinese Academy of Medical Sciences, Huazhong University of Science and Technology, Jiangnan University, Jilin Provincial Tumor Hospital, Shandong University, Sun Yat-Sen University, Wuhan University, Zhejiang University |
| NCT05038839 | Phase 1 | Dec 30, 2021 | University of Texas at Houston |
| NCT04796454 | Phase 2 | Sep 30, 2021 | European Organisation for Research and Treatment of Cancer |
| NCT04985721 | Phase 2 | Aug 1, 2021 | Peter MacCallum Cancer Centre |
| NCT04603365 | Phase 2 | Jan 1, 2021 | BeOne Medicines, Driven To Cure, University of California, Los Angeles |
| NCT04614909 | Early Phase 1 (Phase 1) | Dec 31, 2020 | Barrow Neurological Institute, BeOne Medicines, Ivy Brain Tumor Center, University of Arizona |
| NCT04164199 | Phase 3 | Dec 16, 2019 | BeOne Medicines |
| NCT03991494 | Phase 1 | Jun 30, 2019 | BeOne Medicines |
| NCT03914742 | Phase 1/Phase 2 (Phase 2) | Jun 30, 2019 | BeOne Medicines, Johns Hopkins University, National Cancer Institute (NCI), University of Virginia, Yale University |
Showing 20 of 32 trials
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Organizations
Research & Development (35)
35 organizations
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