← Mechanisms of action
PARP1
SINGLE PROTEINHomo sapiens
Preferred name: Poly [ADP-ribose] polymerase-1 ChEMBL ↗
Linked proteins
Drugs acting on this target (24)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| azd673 | Antagonist | experimental | Small molecule | PARP1 antagonist |
| azd9574 | Antagonist | experimental | Small molecule | parp1 |
| tsl-1502 | Antagonist | experimental | Small molecule | PARP1 antagonist |
| 123i-att001 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| 2x-121 | Inhibitor | experimental | Small molecule | Poly [ADP-ribose] polymerase-1 inhibitor |
| ace-86225106 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| ak-1286 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| bay3713372 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| bcd-236 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| dm5167 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| dsb2455 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| eik1004 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| imp1734 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| jpi-289 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| niraparib (zejula) | Inhibitor | approved | Small molecule | PARP1 inhibitor |
| pamiparib | Inhibitor | experimental | Small molecule | Poly [ADP-ribose] polymerase-1 inhibitor |
| Senaparib | Inhibitor | experimental | Small molecule | Poly [ADP-ribose] polymerase-1 inhibitor |
| snv1521 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| talazoparib (talzenna) | Inhibitor | approved | Small molecule | PARP1 inhibitor |
| tqb3122 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| vb15010 | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| zl-85fa | Inhibitor | experimental | Small molecule | PARP1 inhibitor |
| elu42 | Modulator | experimental | Small molecule | PARP1 modulator |
| pp-01 | Partial agonist | experimental | Small molecule | PARP1 partial agonist |