← Mechanisms of action
KEAP1
SINGLE PROTEINHomo sapiens
Preferred name: Kelch-like ECH-associated protein 1 ChEMBL ↗
Linked proteins
Drugs acting on this target (6)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| omaveloxolone (SKYCLARYS) | Activator | approved | Small molecule | KEAP1 activator |
| sulforaphane | Activator | experimental | Small molecule | KEAP1 activator |
| tepilamide | Activator | experimental | Small molecule | KEAP1 activator |
| dimethyl fumarate (tecfidera) | Inhibitor | approved | Small molecule | KEAP1 inhibitor |
| diroximel (Vumerity) | Inhibitor | approved | Small molecule | Kelch-like ECH-associated protein 1 inhibitor |
| glucoraphanin | Inhibitor | experimental | Small molecule | KEAP1 inhibitor |