sodium monododecyl sulfate
Sodium dodecyl sulfate (SDS) or sodium lauryl sulfate (SLS), sometimes written sodium laurilsulfate, is an organic compound with the formula CH3(CH2)11OSO3Na and structure H3C−(CH2)11−O−S(=O)2−O−Na+. It is an anionic surfactant used in many cleaning and hygiene products. This compound is the sodium salt of the 12-carbon organosulfate. Its hydrocarbon tail combined with a polar "headgroup" give the compound amphiphilic properties that make it useful as a detergent. SDS is also component of mixtures produced from inexpensive coconut and palm oils. SDS is a common component of many domestic cleaning, personal hygiene and cosmetic, pharmaceutical, and food products, as well as of industrial and commercial cleaning and product formulations. — Wikipedia
Clinical trial activity
32 trials · 27 clinical orgs · 0 marketing orgs
Earliest trial started May 1, 2005 (NCT00967174)
Timeline
Indications
Approved for
Studied for
- Acne Vulgaris · Phase 4
- Dermatitis, Atopic · Phase 2
- Dermatology · Phase 1
- Healthy Volunteers · Phase 4
- Hypersensitivity · Phase 4
- Irritants · Phase 1
- Keratosis, Actinic · Phase 3
- Melanosis · Phase 4
- Onychomycosis · Phase 1
- Pain · Phase 1
- Pediculus · Phase 1
- Pruritus · Phase 4
- Psoriasis · Phase 1
- Smoking Cessation · Phase 1
- Surgical Wound Infection · Phase 1
- Tinea Pedis · Phase 1
Mechanism of action
- Unspecified targetSurfactant
surfactant
Chemistry & pharmacology
SMILES
CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+]- Mol. weight
- 288.38 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSodium dodecyl sulfate ↗
- ChEMBLCHEMBL23393 ↗
Also known as
- e487
- e487
- laurylsiran sodny
- laurylsiran sodny
- nads
- nads
- nads
- natrium laurylsulfuricum
- natrium laurylsulfuricum
- sds
- sds
- sls
- sls
- sodium dodecylsulfate
- sodium dodecylsulfate
- sodium dodecyl sulfate
- sodium dodecyl sulfate
- sodium dodecyl sulphate
- sodium dodecyl sulphate
- sodium laurilsulfate
- sodium laurilsulfate
- sodium lauryl sulfate
- sodium lauryl sulfate
- sodium lauryl sulfate
- sodium lauryl sulfate
- sodium lauryl sulfate
- sodium lauryl sulfate
- sodium lauryl sulphate
- sodium lauryl sulphate
- sodium lauryl sulphate
- sodium monododecyl sulfate
- sodium monododecyl sulfate
- sodium monododecyl sulfate
- sodium monododecyl sulfate
- sodium monododecyl sulfate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02589405 | Phase 4 | Aug 1, 2015 | Galderma, Proinnovera GmbH |
| NCT02256930 | Phase 1 | Sep 1, 2014 | Maruho Co., Ltd. |
| NCT02227069 | Phase 1 | Sep 1, 2014 | Maruho Co., Ltd. |
| NCT02218463 | N/A | Sep 1, 2014 | University of Kansas, University of Missouri, University of Missouri, Kansas City |
| NCT02249104 | Phase 4 | Aug 1, 2014 | Galderma, Pflugerville Dermatology Clinical Research |
| NCT02198963 | Phase 1 | Jul 1, 2014 | Bio-Science Laboratories, Pulmatrix Inc. |
| NCT02160574 | Phase 1 | Jun 1, 2014 | Bio-Science Laboratories, Zurex Pharma, Inc. |
| NCT02169154 | Phase 1 | Jun 1, 2014 | GlaxoSmithKline |
| NCT02168478 | Phase 4 | Jun 1, 2014 | Consumer Product Testing Corporation, Medimetriks |
| NCT02117752 | Phase 1 | Apr 1, 2014 | Allergan |
| NCT02061813 | Phase 1 | Jan 1, 2014 | Hatchtech Pty Ltd, TKL Research |
| NCT02062073 | Phase 1 | Jan 1, 2014 | Accelovance, Hatchtech Pty Ltd, TKL Research |
| NCT01984775 | Phase 1 | Oct 30, 2013 | GlaxoSmithKline, Stiefel Laboratories |
| NCT01821274 | Phase 1 | Mar 1, 2013 | Ventrus Biosciences, Inc |
| NCT01816529 | Phase 1 | Mar 1, 2013 | Ventrus Biosciences, Inc |
| NCT01771822 | Phase 1 | Jan 1, 2013 | Pfizer |
| NCT01787448 | Phase 1 | Jan 1, 2013 | Pfizer |
| NCT01638117 | Phase 1 | Apr 1, 2012 | Amorepacific Corporation, Seoul National University |
| NCT01762982 | N/A | Feb 1, 2012 | GlaxoSmithKline |
| NCT01430312 | Phase 1 | Sep 1, 2011 | Bayer |
Organizations
Research & Development (27)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Galderma | For profit | 5 | 4 | 2 | 2006 |
| GlaxoSmithKline | For profit | 5 | 2 | 3 | 2006 |
| Pfizer | For profit | 5 | 5 | 1 | 2007 |
| Bayer | For profit | 2 | 2 | 1 | 2009 |
| Bio-Science Laboratories | For profit | 2 | 0 | 1 | 2014 |
| Hatchtech Pty Ltd | For profit | 2 | 2 | 1 | 2014 |
| Maruho Co., Ltd. | For profit | 2 | 2 | 1 | 2014 |
| Oregon Health and Science University | Academic/Hospital | 2 | 2 | 2 | 2006 |
| Stiefel Laboratories | For profit | 2 | 2 | 1 | 2010 |
| TKL Research | For profit | 2 | 0 | 1 | 2014 |
| Ventrus Biosciences, Inc | For profit | 2 | 2 | 1 | 2013 |
| Wake Forest University | Academic/Hospital | 2 | 2 | 2 | 2006 |
| Accelovance | For profit | 1 | 0 | 1 | 2014 |
| Allergan | For profit | 1 | 1 | 1 | 2014 |
| Amorepacific Corporation | For profit | 1 | 1 | 1 | 2012 |
| Consumer Product Testing Corporation | Academic/Hospital | 1 | 0 | 1 | 2014 |
| McNeil | For profit | 1 | 1 | 1 | 2005 |
| Medimetriks | For profit | 1 | 1 | 1 | 2014 |
| National Eczema Association | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Pflugerville Dermatology Clinical Research | Academic/Hospital | 1 | 0 | 1 | 2014 |