propoxycaine
Small moleculeapproved
Approved
Jul 1, 1952
Propoxycaine hydrochloride is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. Propoxycaine Hydrochloride is the hydrochloride salt form of propoxycaine, a para-aminobenzoic acid ester. Propoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. This results in a loss of sensation. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
Indications
Approved for
Mechanism of action
- Sodium channel alpha subunitBLOCKER
Sodium channel alpha subunit blocker
- Sodium channel protein type 1 subunit alpha (SCN1A) ↗
- Sodium channel protein type 5 subunit alpha (SCN5A) ↗
- Sodium channel protein type 4 subunit alpha (SCN4A) ↗
- Sodium channel protein type 7 subunit alpha (SCN7A) ↗
- Sodium channel protein type 2 subunit alpha (SCN2A) ↗
- Sodium channel protein type 9 subunit alpha (SCN9A) ↗
- Sodium channel protein type 3 subunit alpha (SCN3A) ↗
- Sodium channel protein type 11 subunit alpha (SCN11A) ↗
- Sodium channel protein type 8 subunit alpha (SCN8A) ↗
- Sodium channel protein type 10 subunit alpha (SCN10A) ↗
- Sodium channel protein type I alpha subunit
- Sodium channel protein type V alpha subunit
- Sodium channel protein type IV alpha subunit
- Sodium channel protein type VII alpha subunit
- Sodium channel protein type IX alpha subunit
- Sodium channel protein type II alpha subunit
- Sodium channel protein type III alpha subunit
- Sodium channel protein type XI alpha subunit
- Sodium channel protein type VIII alpha subunit
- Sodium channel protein type X alpha subunit
- Sodium channel alpha subunits; brain (Types I, II, III)
Combination products
ravocaine and novocain w/ levophe
ravocaine and novocain w/ neo-cobefrin
Approval history
- approvedJul 1, 1952
Chemistry & pharmacology
Loading structure…
SMILES
CCCOc1cc(N)ccc1C(=O)OCCN(CC)CC- Mol. weight
- 294.4 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL1195 ↗
- WikipediaPropoxycaine ↗
- NCATSEPD1EH7F53 ↗
- ChEMBLCHEMBL1769 ↗
Also known as
- blockain
- blockain
- blockain hcl
- pravocaine
- propoxycaine
- propoxycaine
- propoxycaine
- propoxycaine
- propoxycaine
- propoxycaine
- propoxycaine
- propoxycaine hcl
- propoxycaine hcl
- propoxycaine hcl
- propoxycaine hydrochloride
- propoxycaine hydrochloride
- propoxycaine hydrochloride
- propoxycaine hydrochloride
- propoxycaine hydrochloride
- propoxycaine hydrochloride
- ranocaine
- ravocaine
- ravocaine hcl