melevodopa
Small moleculeexperimental
Melevodopa, also known as levodopa methyl ester (LDME) and sold under the brand name Levomet, is a dopaminergic agent. It is the methyl ester of levodopa. It is used in oral tablet form as an effervescent prodrug with 250 times the water solubility of tablet levodopa. In combination with carbidopa, as melevodopa/carbidopa, it is approved for use in the treatment of Parkinson's disease. — Wikipedia
Clinical trial activity
1 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2006 (NCT00491998)
Timeline
2000s
- Jan 1, 2006
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1- Mol. weight
- 211.22 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- WikipediaMelevodopa ↗
- ChEMBLCHEMBL1328898 ↗
Also known as
- dl-dopa methyl ester
- dopa methyl ester, (d)-isomer
- l-dopa methyl ester
- l-dopa methyl ester
- l-dopa methyl ester
- l-dopa methyl ester
- l-dopa methyl ester
- l-dopa methyl ester
- levodopa methyl ester
- levodopa methyl ester
- levodopa methyl ester hydrochloride
- levodopa methyl ester hydrochloride, (dl)-isomer
- levomet
- melevodopa
- melevodopa
- melevodopa
- melevodopa
- melevodopa
- methyl l-dopa
- v1512
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00491998 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2006 | Cita NeuroPharmaceuticals, INC Research, Vernalis, Vita-Salute University of Milano. Italy |
Showing 1 of 1 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cita NeuroPharmaceuticals | For profit | 1 | 0 | 1 | 2006 |
| INC Research | For profit | 1 | 0 | 1 | 2006 |
| Vernalis | For profit | 1 | 1 | 1 | 2006 |
| Vita-Salute University of Milano. Italy | Academic/Hospital | 1 | 0 | 1 | 2006 |
4 organizations
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