dopexamine
Small moleculeexperimental
Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce exacerbations of heart failure and to treat heart failure following cardiac surgery. It is not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work as well. It works by stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also inhibits the neuronal re-uptake of norepinephrine. — Wikipedia
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
0
Phase 4
1
Earliest trial started Mar 1, 2002 (NCT00134212)
Timeline
2000s
- Jan 1, 2002
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O- Mol. weight
- 356.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDopexamine ↗
- ChEMBLCHEMBL77622 ↗
- ChEMBLCHEMBL2106203 ↗
Also known as
- dopacard
- dopacard
- dopacard
- dopexamine
- dopexamine
- dopexamine
- dopexamine
- dopexamine
- dopexamine
- dopexamine
- dopexamine
- dopexamine dihydrobromide
- dopexamine dihydrochloride
- dopexamine hcl
- dopexamine hcl
- dopexamine hydrochloride
- dopexamine hydrochloride
- dopexamine hydrochloride
- fpl 60278
- fpl-60278
- fpl-60278
- fpl-60278ar
- fpl-60278ar
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01418118 | Phase 4 | Oct 1, 2008 | University of Oxford |
| NCT00134212 | Phase 2 | Mar 1, 2002 | University of Rennes |
Showing 2 of 2 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Oxford | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Rennes | Academic/Hospital | 1 | 1 | 1 | 2002 |
2 organizations
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