minaprine
Minaprine is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Mechanism of action
- Serotonin 2 (5-HT2) receptorANTAGONIST
Serotonin 2 (5-HT2) receptor
- Dopamine D1 and D2 receptorAGONIST
Dopamine D1 and D2 receptor agonist
Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of monoamine oxidase. It has also been found to inhibit acetylcholinesterase in a reversible and competitive way.
IC50= 85µM on homogenized rat striatum acetylcholinesterase.
- Serotonin 2 (5-HT2) receptorANTAGONIST
Serotonin 2 (5-HT2) receptor antagonist
Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of monoamine oxidase. It has also been found to inhibit acetylcholinesterase in a reversible and competitive way.
IC50= 85µM on homogenized rat striatum acetylcholinesterase.
CHRM1 agonist
Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of monoamine oxidase. It has also been found to inhibit acetylcholinesterase in a reversible and competitive way.
IC50= 85µM on homogenized rat striatum acetylcholinesterase.
- AcetylcholinesteraseINHIBITOR
ACHE inhibitor
Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of monoamine oxidase. It has also been found to inhibit acetylcholinesterase in a reversible and competitive way.
IC50= 85µM on homogenized rat striatum acetylcholinesterase.
- Monoamine oxidase AINHIBITOR
MAOA inhibitor
Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of monoamine oxidase. It has also been found to inhibit acetylcholinesterase in a reversible and competitive way.
IC50= 85µM on homogenized rat striatum acetylcholinesterase.
Chemistry & pharmacology
SMILES
Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1.Cl.Cl- Mol. weight
- 371.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1364551 ↗
- WikipediaMinaprine ↗
- ChEMBLCHEMBL536932 ↗
- ChEMBLCHEMBL278819 ↗
- ChEMBLCHEMBL1200731 ↗
Also known as
- 30038cb
- 30038cb
- 30038cm
- 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl pyridazine, dihydrochloride
- 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine
- 4-(2-((4-methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine
- 4-(2-((4-methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine
- 4-methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin
- 4-methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin
- agr 1240
- agr 1240
- agr-1240
- agr-1240
- brantur
- brantur
- cantor
- cantor
- cantor
- cb-30038
- cb-30038
- minaprina
- minaprina
- minaprine
- minaprine
- minaprine
- minaprine
- minaprine
- minaprine
- minaprine
- minaprine
- minaprine dihydrochloride
- minaprine dihydrochloride
- minaprine hcl
- minaprine hcl
- minaprine hcl
- minaprine hydrochloride
- minaprine hydrochloride
- minaprine hydrochloride
- minaprine hydrochloride
- minaprinum
- minaprinum
- mineprine
- n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
- n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
- n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine