bivalent oral polio vaccine (bopv), type 1 and type 3
Trade name: BOPV
Vaccineapproved
Approved
Dec 1, 2009
Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used: an inactivated poliovirus given by injection (IPV) and a weakened poliovirus given by mouth (OPV). The World Health Organization (WHO) recommends all children be fully vaccinated against polio. The two vaccines have eliminated polio from most of the world, and reduced the number of cases reported each year from an estimated 350,000 in 1988 to 33 in 2018. — Wikipedia
Clinical trial activity
59 trials · 54 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
29
Phase 3
23
Phase 4
20
Earliest trial started Oct 1, 1999 (NCT02961595)
Timeline
Indications
Approved for
Studied for
- Breast Neoplasms · Phase 2
- Colonic Neoplasms · Phase 2
- Colorectal Neoplasms · Phase 1
- COVID-19 · Phase 4
- Diabetes Mellitus, Type 1 · Phase 1
- Diphtheria · Phase 3
- Diphtheria-Tetanus-Pertussis Vaccine · Phase 4
- Diphtheria Toxoid · Phase 3
- Enterovirus Infections · Phase 1
- Gastroenteritis · Phase 3
- Haemophilus Infections · Phase 3
- Haemophilus influenzae · Phase 3
- Haemophilus influenzae type b · Phase 3
- Healthy Volunteers · Phase 4
- Hepatitis B · Phase 3
- Immunity, Heterologous · Phase 4
- Influenza, Human · Phase 3
- Malaria · Phase 2
- Measles · Phase 3
- Measles-Mumps-Rubella Vaccine · Phase 4
- Melanoma · Phase 1
- Morbidity · Phase 4
- Mortality · Phase 4
- Pertussis Vaccine · Phase 3
- Pneumococcal Infections · Phase 3
- Poliomyelitis · Phase 4
- Poliovirus Vaccine, Oral · Phase 4
- Poliovirus Vaccines · Phase 4
- Prediabetic State · Phase 1
- Rotavirus Infections · Phase 3
- SARS-CoV-2 · Phase 3
- Severe Acute Respiratory Syndrome · Phase 3
- Tetanus · Phase 3
- Urinary Bladder Neoplasms · Phase 2
- Vaccination · Phase 4
- Vaccination Coverage · Phase 4
- Vaccines · Phase 4
- Whooping Cough · Phase 4
Mechanism of action
- PoliovirusImmunity, active
Poliovirus immunity, active
Approval history
- approvedDec 1, 2009
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPolio vaccine ↗
Also known as
- bivalent oral polio vaccine
- bivalent oral polio vaccine (bopv), type 1 and type 3
- bivalent oral poliovirus vaccine
- bopv
- live oral polio vaccine
- opv
- opv
- oral poliovirus vaccine
- polio vaccine
- poliovirus vaccine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06920069 | Phase 4 | May 15, 2025 | Chinese Academy of Medical Sciences |
| NCT06748612 | Phase 4 | Jan 28, 2025 | International Center for Diarrheal Disease Research |
| NCT06137664 | Phase 1/Phase 2 (Phase 2) | Dec 29, 2023 | PATH |
| NCT06114810 | Phase 4 | Nov 30, 2023 | Centers for Disease Control and Prevention (CDC), Government of Bangladesh, International Center for Diarrheal Disease Research |
| NCT06752174 | Phase 3 | Mar 8, 2023 | Beijing Minhai Biotechnology Co., Ltd |
| NCT05155579 | Phase 1 | Feb 28, 2022 | Malaria Research and Training Center, Bamako, Mali, University of Oxford |
| NCT05077137 | Phase 1 | Sep 7, 2021 | Duke University |
| NCT05166031 | Phase 3 | Dec 31, 2020 | Bill and Melinda Gates Foundation, Fidec Corporation |
| NCT04576910 | Phase 4 | Nov 5, 2020 | China National Biotec Group Co., Ltd, Government of China |
| NCT04540185 | Phase 3 | Nov 1, 2020 | Biomed Industries, Inc., Coronavirus Research Institute, NeuroActiva |
| NCT04579510 | Phase 2 | Oct 11, 2020 | Centers for Disease Control and Prevention (CDC), International Center for Diarrheal Disease Research |
| NCT04504539 | N/A | Aug 31, 2020 | Aga Khan University, World Health Organization |
| NCT04445428 | Phase 4 | Jul 15, 2020 | Bandim Health Project |
| NCT04429295 | Phase 3 | Jun 29, 2020 | Sanofi-Aventis |
| NCT04232943 | Phase 1 | Jan 28, 2020 | PATH |
| NCT04054752 | Phase 1 | Aug 16, 2019 | National Cancer Institute (NCI), NeoImmuneTech, Inc. |
| NCT03722004 | Phase 4 | Dec 18, 2018 | Centers for Disease Control and Prevention (CDC), International Center for Diarrheal Disease Research |
| NCT03822767 | Phase 3 | Jun 12, 2018 | Government of China, Sinovac Biotech Co., Ltd |
| NCT03822754 | Phase 3 | Jun 6, 2018 | Government of China, Sinovac Biotech Co., Ltd |
| NCT04054492 | Phase 4 | Mar 1, 2018 | China National Biotec Group Co., Ltd, Government of China, Inner Mongolia Autonomous Region Center for Diseases Prevention and Control (IMCDC), Peking University |
Showing 20 of 59 trials
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Organizations
Research & Development (54)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| International Center for Diarrheal Disease Research | Academic/Hospital | 11 | 3 | 3 | 2012 |
| Centers for Disease Control and Prevention (CDC) | Government | 10 | 7 | 4 | 2012 |
| Government of China | Government | 8 | 3 | 3 | 2009 |
| Bill and Melinda Gates Foundation | Academic/Hospital | 7 | 0 | 3 | 2013 |
| Sanofi | For profit | 6 | 6 | 2 | 2006 |
| Aga Khan University | Academic/Hospital | 5 | 5 | 2 | 2012 |
| PATH | Academic/Hospital | 5 | 3 | 3 | 2011 |
| World Health Organization | Government | 5 | 0 | 2 | 2012 |
| GlaxoSmithKline | For profit | 4 | 4 | 2 | 2005 |
| Bandim Health Project | Government | 3 | 3 | 2 | 2008 |
| China National Biotec Group Co., Ltd | For profit | 3 | 1 | 1 | 2017 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 3 | 3 | 3 | 2009 |
| Fidec Corporation | Academic/Hospital | 3 | 3 | 2 | 2013 |
| National Institutes of Health (NIH) | Government | 3 | 0 | 2 | 2011 |
| Beijing Tiantan Bio Co., Ltd | For profit | 2 | 0 | 1 | 2015 |
| Government of Bangladesh | Academic/Hospital | 2 | 0 | 2 | 2012 |
| National Cancer Institute (NCI) | Government | 2 | 2 | 2 | 2011 |
| Sanofi-Aventis | For profit | 2 | 1 | 2 | 2011 |
| Serum Institute of India Pvt. Ltd. | For profit | 2 | 1 | 1 | 2015 |
| Sinovac Biotech Co., Ltd | For profit | 2 | 2 | 1 | 2018 |
54 organizations
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