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triptorelin

Trade name: Trelstar

Peptideapproved

Approved

Jun 15, 2000

Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). It works by decreasing the production of certain hormones, which reduces testosterone levels in the body. Animal studies comparing triptorelin to native GnRH found that triptorelin had 13 fold higher releasing activity for luteinizing hormone, and 21-fold higher releasing activity for follicle-stimulating hormone. Triptorelin is indicated for the palliative treatment of advanced prostate cancer. — NCATS

Clinical trial activity

198 trials · 227 clinical orgs · 7 marketing orgs

Phase 1
8
Phase 2
99
Phase 3
73
Phase 4
46

Earliest trial started Apr 1, 1997 (NCT00003026)

Timeline

1980s

  1. Jun 1, 1986

    Lederle — IND Organization

  2. Jun 1, 1986

    Lederle — IND Organization

1990s

  1. Jan 1, 1997

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jun 15, 2000

    Debiopharm — Earliest FDA Approval

  2. Jun 15, 2000

    Verity Pharmaceuticals — Marketing Organization

  3. Jun 15, 2000

    Allergan — Marketing Organization

  4. Jun 15, 2000

    Allergan — NDA Secondary Org

  5. Jun 15, 2000

    Debiopharm — NDA Organization

  6. Jun 15, 2000

    Verity Pharmaceuticals — NDA Secondary Org

  7. Jan 1, 2001

    Earliest Phase 2 Sponsor(trial)

  8. Jan 1, 2009

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jun 29, 2017

    Azurity — Marketing Organization

  2. Jun 29, 2017

    Arbor Pharmaceuticals — NDA Secondary Org

  3. Jun 29, 2017

    Azurity — NDA Secondary Org

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedJun 15, 2000

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
Mol. weight
1311.47 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only
Multi-specific
No

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • (6-d-tryptophan)luteinizing hormone-releasing hormone
  • (6-d-tryptophan)luteinizing hormone-releasing hormone
  • arvekap
  • cl-118532
  • cl-118532
  • decapeptyl
  • decapeptyl
  • decapeptyl
  • (d-trp6)-gnrh
  • (d-trp6)-gnrh
  • gonapeptyl
  • gonapeptyl
  • luteinizing hormone-releasing factor (pig), 6-d-tryptophan
  • luteinizing hormone-releasing factor (pig), 6-d-tryptophan
  • pglu-his-trp-ser-tyr-d-trp-leu-arg-pro-gly-nh2
  • pglu-his-trp-ser-tyr-d-trp-leu-arg-pro-gly-nh2
  • trelstar
  • trelstar
  • trelstar depot
  • trelstar depot
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelin
  • triptorelina
  • triptorelina
  • triptorelin acetate
  • triptorelin acetate
  • triptoreline
  • triptoreline
  • triptoreline
  • triptoreline
  • triptorelin embonate
  • triptorelin embonate
  • triptorelin pamoate
  • triptorelin pamoate
  • triptorelin pamoate
  • triptorelin pamoate
  • triptorelinum
  • triptorelinum
  • tryptorelin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07254429Phase 2Oct 2, 2025University of Copenhagen
NCT06795178Phase 3Jul 1, 2025Foresee Pharmaceuticals Co., Ltd., QPS
NCT06913075N/AJun 25, 2025Indira IVF Hospital Pvt Ltd
NCT06795191Phase 3Jun 1, 2025Foresee Pharmaceuticals Co., Ltd., QPS
NCT06513962Phase 3Feb 10, 2025National Cancer Institute (NCI)
NCT06683066Phase 1Dec 4, 2024Central Hospital, Zibo, Central South University, Chongqing Medical University, People's Hospital Of Yichang, Qingdao University, Shandong University, Shanxi Medical University, Sichuan University, Yuncheng Central Hospital
NCT06487143Phase 4Jul 1, 2024Sun Yat-Sen University
NCT06378866Phase 2Jun 3, 2024Mayo Clinic
NCT06481696N/AJun 1, 2024Andros Day Surgery Clinic
NCT06150703Phase 3Feb 29, 2024Assistance Publique - Hôpitaux de Paris
NCT06225284Phase 2Feb 15, 2024Debiopharm, National Taiwan University
NCT06525155Phase 3Jan 2, 2024Dexa Medica Group, Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
NCT06146413Phase 2Dec 30, 2023Bedaya Hospital, Cairo University
NCT06581679N/ADec 15, 2023Zagazig University
NCT06282588Phase 2/Phase 3 (Phase 3)Dec 13, 2023Bayer, Cancer Research Antwerp, University of Antwerp, Veracyte, Inc.
NCT05896566Phase 2Dec 1, 2023ETOP IBCSG Partners Foundation, Roche
NCT05982093Phase 2Aug 31, 2023SOLTI Breast Cancer Research Group
NCT05972902Phase 3Jul 15, 2023Beni Suef University
NCT05851547Phase 2Jun 30, 2023Knight Therapeutics, University of Ottawa
NCT05781217Phase 3Mar 14, 2023Fundación Española de Oncología Radioterápic
Showing 20 of 198 trials
Page 1 / 10

Organizations

Research & Development (227)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
IpsenFor profit181532002
National Cancer Institute (NCI)Government15122003
Tel Aviv UniversityAcademic/Hospital7632014
University of MilanAcademic/Hospital7132001
Cairo UniversityAcademic/Hospital6332011
Harvard UniversityAcademic/Hospital5322002
International Breast Cancer Study GroupAcademic/Hospital5522003
University of ValenciaAcademic/Hospital5522005
Damascus UniversityAcademic/Hospital4412019
DebiopharmFor profit4322006
EugoniaAcademic/Hospital4322003
Fudan UniversityAcademic/Hospital4322016
Mansoura UniversityAcademic/Hospital4422014
MerckFor profit4132007
NRG OncologyAcademic/Hospital4212009
UNICANCERAcademic/Hospital4412002
Free University of BrusselsAcademic/Hospital3312012
Government of ChinaGovernment3112012
Katholieke Universiteit LeuvenAcademic/Hospital3232013
Nanjing UniversityAcademic/Hospital3322012
227 organizations
Page 1 / 12

Marketing (10)

OrganizationOrg typeRelationshipDate
AllerganFor profitMKTGJun 15, 2000
AllerganFor profitNDA2Jun 15, 2000
Arbor PharmaceuticalsFor profitNDA2Jun 29, 2017
AzurityFor profitMKTGJun 29, 2017
AzurityFor profitNDA2Jun 29, 2017
DebiopharmFor profitNDAJun 15, 2000
LederleFor profitINDJun 1, 1986
Verity PharmaceuticalsFor profitMKTGJun 15, 2000
Verity PharmaceuticalsFor profitNDA2Jun 15, 2000
Watson PharmaceuticalsFor profitMKTG—