allogeneic bone marrow
Cell therapyexperimental
Bone marrow is a semi-solid tissue found within the spongy portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production. It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. In adult humans, bone marrow is primarily located in the ribs, vertebrae, sternum, and bones of the pelvis. Bone marrow comprises approximately 5% of total body mass in healthy adult humans, such that a person weighing 73 kg (161 lbs) will have around 3.7 kg (8 lbs) of bone marrow. — Wikipedia
Clinical trial activity
91 trials · 77 clinical orgs · 0 marketing orgs
Phase 1
22
Phase 2
55
Phase 3
14
Phase 4
2
Earliest trial started Aug 1, 1987 (NCT00002547)
Timeline
Indications
Approved for
Studied for
- Anemia, Aplastic · Phase 3
- Anemia, Sickle Cell · Phase 2
- Autoimmune Diseases · Phase 2
- Autoimmune Diseases of the Nervous System · Phase 2
- Bone Marrow Transplantation · Phase 2
- Breast Neoplasms · Phase 1/Phase 2
- Bronchiectasis · Phase 2
- Burkitt Lymphoma · Phase 3
- Cardiomyopathy, Dilated · Phase 2
- Cerebellar Diseases · Phase 2
- Craniofacial Abnormalities · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 2
- Encephalitis · Phase 2
- Epidermolysis Bullosa · Phase 2
- Facial Injuries · Phase 2
- Facial Transplantation · Phase 2
- Fanconi Anemia · Phase 2/Phase 3
- Fractures, Ununited · Phase 1/Phase 2
- Fusion Proteins, bcr-abl · Phase 2
- Graft Survival · Phase 2
- Graft vs Host Disease · Phase 3
- Head and Neck Neoplasms · Phase 2
- Heart Failure · Phase 2
- Hematologic Diseases · Phase 2
- Hematologic Neoplasms · Phase 2
- Hematopoietic Stem Cell Transplantation · Phase 2
- HIV Infections · Phase 1
- Hodgkin Disease · Phase 3
- Kidney Failure, Chronic · Phase 2
- Kidney Neoplasms · Phase 2
- Kidney Transplantation · Phase 2
- Lambert-Eaton Myasthenic Syndrome · Phase 2
- Leukemia · Phase 3
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 2
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive · Phase 2
- Leukemia, Myeloid, Acute · Phase 4
- Leukemia, Plasma Cell · Phase 2
- Leukemia, Prolymphocytic · Phase 2
- Liver Neoplasms · Phase 2
- Lymphoma · Phase 3
- Lymphoma, B-Cell · Phase 2
- Lymphoma, Follicular · Phase 3
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Mantle-Cell · Phase 3
- Lymphoma, Non-Hodgkin · Phase 3
- Multiple Myeloma · Phase 3
- Multiple Sclerosis · Phase 2
- Myasthenia Gravis · Phase 2
- Myeloablative Agonists · Phase 2
- Myelodysplastic-Myeloproliferative Diseases · Phase 3
- Myelodysplastic Syndromes · Phase 4
- Myeloproliferative Disorders · Phase 2
- Neoplasms · Phase 2
- Neuroblastoma · Phase 2
- Neuromyelitis Optica · Phase 2
- Opsoclonus-Myoclonus Syndrome · Phase 2
- Organ Transplantation · Phase 2
- Osteoarthritis · Phase 2/Phase 3
- Osteoarthritis, Knee · Phase 3
- Osteogenesis Imperfecta · Phase 1
- Osteopetrosis · Phase 2/Phase 3
- Ovarian Neoplasms · Phase 2
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating · Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 2
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 3
- Prostatic Neoplasms · Phase 1
- Pseudarthrosis · Phase 1/Phase 2
- Retinoblastoma · Phase 2
- Sarcoma · Phase 2
- Scleroderma, Systemic · Phase 1/Phase 2
- Sclerosis · Phase 1/Phase 2
- Severe Combined Immunodeficiency · Phase 1/Phase 2
- Spinal Fusion · Phase 4
- Stiff-Person Syndrome · Phase 2
- Testicular Neoplasms · Phase 2
- Traumatology · Phase 2
- Ulcer · Phase 1
- Vasculitis, Central Nervous System · Phase 2
Mechanism of action
- Unspecified targetTissue restoration
tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBone marrow ↗
- WikipediaBone marrow examination ↗
Also known as
- bone marrow
- bone marrow aspirate
- bone marrow cell
- bone marrow cells
- haploidentical bone marrow
- hla-matched related donor bone marrow
- in vitro-treated bone marrow
- non-t-cell depleted bone marrow
- unrelated bone marrow
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06517641 | Phase 2 | Sep 1, 2024 | Medical College of Wisconsin, National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI), Sanofi |
| NCT06238934 | Phase 3 | Mar 31, 2024 | Instituto Nacional de Traumatologia e Ortopedia |
| NCT05579769 | Phase 2 | Nov 4, 2022 | St. Jude Children's Hospital |
| NCT04826224 | Phase 1 | Apr 6, 2021 | Mayo Clinic |
| NCT04248192 | Phase 1 | Mar 31, 2020 | Children's National Medical Center, Georgetown University, Johns Hopkins University |
| NCT04166929 | Phase 2 | Nov 15, 2019 | Government of Italy, Universita' Cattolica del Sacro Cuore |
| NCT04013841 | N/A | Aug 1, 2019 | National Cancer Institute (NCI), Vilnius University |
| NCT03867617 | Phase 1/Phase 2 (Phase 2) | Apr 30, 2019 | Medical University of Vienna, University of Regensburg |
| NCT03271229 | Phase 2 | Jan 31, 2019 | Mayo Clinic |
| NCT03790189 | N/A | Jan 31, 2019 | Istituto Clinico Humanitas - Rozzano (MI), Italy |
| NCT04188678 | N/A | Sep 28, 2018 | Johns Hopkins University, National Institute on Aging (NIA), National Institutes of Health (NIH) |
| NCT05191732 | N/A | Aug 3, 2018 | Government of Taiwan, Kaohsiung Medical University |
| NCT03572660 | Phase 2 | Jul 15, 2018 | Barts & The London NHS Trust |
| NCT03372954 | Phase 2 | Jan 31, 2018 | University of Ostrava |
| NCT02995655 | Phase 1 | Apr 7, 2017 | Cantex Pharmaceuticals, Washington University in St. Louis |
| NCT02582489 | N/A | Apr 1, 2017 | Rush University |
| NCT02661035 | Phase 2 | Mar 9, 2017 | University of Minnesota |
| NCT02995330 | Phase 1 | Jan 1, 2017 | Johns Hopkins University |
| NCT02924571 | Phase 4 | Dec 1, 2016 | New York University |
| NCT02905994 | Phase 1 | Sep 1, 2016 | Boehringer Ingelheim, Harvard University |
Showing 20 of 91 trials
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Organizations
Research & Development (77)
77 organizations
Page 1 / 4