← Mechanisms of action
Mitochondrial complex I (NADH dehydrogenase)
PROTEIN COMPLEXHomo sapiens
Linked proteins
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (NDUFA1) ↗
- NADH-ubiquinone oxidoreductase chain 6 (MT-ND6) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (NDUFS8) ↗
- NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) ↗
- NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (NDUFB6) ↗
- Cytochrome c oxidase subunit NDUFA4 (NDUFA4) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (NDUFA11) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (NDUFB7) ↗
- NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (NDUFS2) ↗
- NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NDUFS4) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (NDUFB3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (NDUFA8) ↗
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (NDUFC1) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (NDUFA2) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (NDUFS5) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) ↗
- NADH-ubiquinone oxidoreductase chain 4 (MT-ND4) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (NDUFS7) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (NDUFS6) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (NDUFB1) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12) ↗
- NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) ↗
- Acyl carrier protein, mitochondrial (NDUFAB1) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (NDUFS3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (NDUFA3) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (NDUFB4) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (NDUFA7) ↗
- NADH dehydrogenase [ubiquinone] 1 subunit C2 (NDUFC2) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (NDUFB10) ↗
- NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2) ↗
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) ↗
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1) ↗
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (NDUFV3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (NDUFA5) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (NDUFAF2) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (NDUFAF3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13) ↗
- Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) ↗
Drugs acting on this target (3)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| me-344 | Inhibitor | experimental | Small molecule | Mitochondrial complex I (NADH dehydrogenase) inhibitor |
| metformin (glucophage) | Inhibitor | approved | Small molecule | Mitochondrial complex I (NADH dehydrogenase) inhibitor |
| nv-128 | Inhibitor | experimental | Small molecule | Mitochondrial complex I (NADH dehydrogenase) inhibitor |