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nv-128

Small moleculeexperimental

Clinical trial activity

0 trials · 0 clinical orgs · 0 marketing orgs

Phase 1

0

Phase 2

0

Phase 3

0

Phase 4

0

Mechanism of action

Mitochondrial complex I (NADH dehydrogenase)INHIBITOR
Mitochondrial complex I (NADH dehydrogenase) inhibitor
Prodrug - active metabolite is ME-344. Mitochondrial inhibitor, specific molecular target for ME-344 has not been completely defined but has been shown to inhibit mitochondrial oxidative phosphorylation (OXPHOS) complex I (PMID:25973307), may also inhibit the mTORC1-and mTORC2-dependent pathways (PMID:25411085, http://mct.aacrjournals.org/content/12/11_Supplement/A17.short).

Chemistry & pharmacology

Chirality: Single Stereoisomer
Inorganic: No
Polymer: No

Oral

No

Parenteral

No

Topical

No

Sources

ChEMBLCHEMBL3545135 ↗

Also known as

nv-128
nv-128