me-344
Small moleculeexperimental
Clinical trial activity
3 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2012 (NCT01544322)
Timeline
2010s
- Jan 1, 2012
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
Mitochondrial complex I (NADH dehydrogenase) inhibitor
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (NDUFA1) ↗
- NADH-ubiquinone oxidoreductase chain 6 (MT-ND6) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (NDUFS8) ↗
- NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) ↗
- NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (NDUFB6) ↗
- Cytochrome c oxidase subunit NDUFA4 (NDUFA4) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (NDUFA11) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (NDUFB7) ↗
- NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (NDUFS2) ↗
- NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NDUFS4) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (NDUFB3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (NDUFA8) ↗
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (NDUFC1) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (NDUFA2) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (NDUFS5) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) ↗
- NADH-ubiquinone oxidoreductase chain 4 (MT-ND4) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (NDUFS7) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (NDUFS6) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (NDUFB1) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12) ↗
- NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) ↗
- Acyl carrier protein, mitochondrial (NDUFAB1) ↗
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (NDUFS3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (NDUFA3) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (NDUFB4) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (NDUFA7) ↗
- NADH dehydrogenase [ubiquinone] 1 subunit C2 (NDUFC2) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (NDUFB10) ↗
- NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2) ↗
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) ↗
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1) ↗
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (NDUFV3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (NDUFA5) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (NDUFAF2) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (NDUFAF3) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4) ↗
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13) ↗
- Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) ↗
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) ↗
- NADH-ubiquinone oxidoreductase MLRQ subunit
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
- NADH-ubiquinone oxidoreductase 49 kDa subunit
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase SGDH subunit
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
- NADH-ubiquinone oxidoreductase 42 kDa subunit
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
- NADH-ubiquinone oxidoreductase B17 subunit
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
- NADH-ubiquinone oxidoreductase B18 subunit
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
- NADH-ubiquinone oxidoreductase chain 1
Chemistry & pharmacology
Loading structure…
SMILES
Cc1c(O)ccc2c1OC[C@@H](c1ccc(O)cc1)[C@H]2c1ccc(O)cc1- Mol. weight
- 348.4 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5314386 ↗
- ChEMBLCHEMBL3545320 ↗
Also known as
- me-344
- me-344
- me-344
- me-344
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02806817 | Early Phase 1 (Phase 1) | Jul 1, 2016 | Fundación CRIS, Universidad Carlos III Madrid |
| NCT02100007 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2014 | MEI Pharma, SCRI Development Innovations |
| NCT01544322 | Phase 1 | May 1, 2012 | MEI Pharma, SCRI Development Innovations |
Showing 3 of 3 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| MEI Pharma | For profit | 2 | 2 | 2 | 2012 |
| SCRI Development Innovations | For profit | 2 | 0 | 2 | 2012 |
| Fundación CRIS | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Universidad Carlos III Madrid | Academic/Hospital | 1 | 1 | 1 | 2016 |
4 organizations
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