← Mechanisms of action
BTK
SINGLE PROTEINHomo sapiens
Preferred name: Tyrosine-protein kinase BTK ChEMBL ↗
Linked proteins
Drugs acting on this target (66)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| as-1763 | Antagonist | experimental | Small molecule | BTK antagonist |
| gb5121 | Antagonist | experimental | Small molecule | BTK |
| hmpl-760 | Antagonist | experimental | Small molecule | BTK antagonist |
| img-004 | Antagonist | experimental | Small molecule | BTK |
| pirtobrutinib (Jaypirca) | Antagonist | approved | Small molecule | BTK antagonist |
| tt-01488 | Antagonist | experimental | Small molecule | BTK antagonist |
| zanubrutinib (Brukinsa) | Antagonist | approved | Small molecule | BTK antagonist |
| abbv-101 | Degrader | experimental | Nucleic acid | BTK degrader |
| ac676 | Degrader | experimental | Small molecule | BTK degrader |
| bgb-16673 | Degrader | experimental | Small molecule | BTK degrader |
| ubx-303061 | Degrader | experimental | Small molecule | BTK degrader |
| abbv-992 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| abivertinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| ac0058ta | Inhibitor | experimental | Small molecule | BTK inhibitor |
| acalabrutinib (calquence) | Inhibitor | approved | Small molecule | BTK inhibitor |
| apg-3288 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| Atuzabrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| bi 1482694 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| bi 705564 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| biib068 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| biib091 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| bms-986196 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| bn102 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| Branebrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| ct-1530 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| dtrm-505 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| dtrm-555 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| dtrmwxhs-12 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| dwp213388 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| dzd8586 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| elsubrutinib | Inhibitor | experimental | Small molecule | Tyrosine-protein kinase BTK inhibitor |
| ever001 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| evobrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| fenebrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| gdc-0853 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| hsk29116 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| hwh486 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| hz-a-018 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| ibrutinib (imbruvica) | Inhibitor | approved | Small molecule | BTK inhibitor |
| irbinitinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| jnj-42721458 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| lp-168 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| m7583 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| msc-2364447 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| nemtabrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| nx-2127 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| nx-5948 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| ono-4059 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| orelabrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| pirtobrutinib (Jaypirca) | Inhibitor | approved | Small molecule | Tyrosine-protein kinase BTK inhibitor |
| Poseltinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| Remibrutinib | Inhibitor | approved | Small molecule | BTK inhibitor |
| Rilzabrutinib | Inhibitor | approved | Small molecule | BTK inhibitor |
| sar446268 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| shr1459 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| sns-062 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| spebrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| tak-020 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| tas5315 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| tg-1701 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| tirabrutinib | Inhibitor | experimental | Small molecule | Tyrosine-protein kinase BTK inhibitor |
| tolebrutinib | Inhibitor | experimental | Small molecule | BTK inhibitor |
| tqb3019 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| vt7208 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| xs-04 | Inhibitor | experimental | Small molecule | BTK inhibitor |
| zanubrutinib (Brukinsa) | Inhibitor | approved | Small molecule | Tyrosine-protein kinase BTK inhibitor |