CDEK
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orelabrutinib

Small moleculeexperimental

Clinical trial activity

83 trials · 66 clinical orgs · 0 marketing orgs

Phase 1
13
Phase 2
69
Phase 3
13
Phase 4
0

Earliest trial started Jul 4, 2017 (NCT03189017)

Timeline

2010s

  1. Jan 1, 2017

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2019

    Earliest Phase 2 Sponsor(trial)

2020s

  1. Jan 1, 2020

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C=CC(=O)N1CCC(c2ccc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)CC1
Mol. weight
427.5 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • icp-022

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07299019Phase 3Mar 31, 2026Zenas BioPharma (USA), LLC
NCT06958705Phase 2Dec 1, 2025AbbVie, Nanjing Medical University
NCT07206264Phase 2Oct 31, 2025Tianjin Medical University
NCT07067463Phase 3Sep 30, 2025Beijing InnoCare Pharma Tech Co., Ltd.
NCT07191431N/ASep 22, 2025Jiao Tong University
NCT07247383Phase 2Sep 19, 2025Zhejiang University
NCT07272499Phase 2Sep 10, 2025Anhui Medical University, Central South University, Fudan University, Fujian Medical University, Jiao Tong University, Shandong University, Tongji University, Wenzhou Medical University
NCT07208981Phase 2Aug 14, 2025Nanjing Medical University
NCT07257510N/AAug 1, 2025Peking University
NCT07199296Phase 2Jul 1, 2025Anhui Medical University, Central South University, Fudan University, Fujian Medical University, Jiao Tong University, Shandong University, Wenzhou Medical University
NCT07078500Phase 2May 5, 2025Chinese Academy of Medical Sciences, Dongyang People's Hospital, Huzhou University, Nanchang University, Ningbo No. 5 Hospital, People's Hospital of Quzhou, Shaoxing Central Hospital, Shaoxing People's Hospital, The Central Hospital of Lishui City, Wenzhou Medical University, Yuyao People's Hospital of Zhejiang Province, Zhejiang University, Zhuji People's hospital
NCT06901999Phase 2Apr 30, 2025Jiao Tong University
NCT07022223Phase 2Mar 11, 2025Chinese Academy of Medical Sciences, Dongyang People's Hospital, Huzhou University, Nanchang University, Ningbo No. 5 Hospital, People's Hospital of Quzhou, Shaoxing Central Hospital, Shaoxing People's Hospital, The Central Hospital of Lishui City, Wenzhou Medical University, Yuyao People's Hospital of Zhejiang Province, Zhejiang University, Zhuji People's hospital
NCT06793189Phase 2Jan 21, 2025Jiao Tong University
NCT06656221Phase 2Dec 1, 2024Jiao Tong University
NCT06700798Phase 2Nov 28, 2024Nanchang University
NCT06701357Phase 2Nov 25, 2024Jiao Tong University
NCT06647940Phase 2Nov 1, 2024Gansu Provincial Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou Medical University, Shantou University, Shenzhen University, Southern Medical University, Sun Yat-Sen University, The First People's Hospital of Zhaoqing City
NCT06516978Phase 2Oct 1, 2024Nanjing Medical University
NCT06583837Phase 2Sep 10, 2024Fudan University
Showing 20 of 83 trials
Page 1 / 5

Organizations

Research & Development (66)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Beijing InnoCare Pharma Tech Co., Ltd.For profit272642017
Jiao Tong UniversityAcademic/Hospital121232021
Chinese Academy of Medical SciencesAcademic/Hospital9422018
Zhejiang UniversityAcademic/Hospital7712021
Nanchang UniversityAcademic/Hospital6212023
Nanjing Medical UniversityAcademic/Hospital6522018
Wenzhou Medical UniversityAcademic/Hospital6012021
Fudan UniversityAcademic/Hospital5322021
Peking UniversityAcademic/Hospital5322020
Shandong UniversityAcademic/Hospital5212021
Fujian Medical UniversityAcademic/Hospital4032024
Sun Yat-Sen UniversityAcademic/Hospital4412021
Anhui Medical UniversityAcademic/Hospital3022024
Central South UniversityAcademic/Hospital3022024
Southern Medical UniversityAcademic/Hospital3122023
Capital Medical UniversityAcademic/Hospital2012021
Dalian Medical UniversityAcademic/Hospital2022021
Dongyang People's HospitalAcademic/Hospital2012025
Guangzhou Medical UniversityAcademic/Hospital2012021
Henan Medical UniversityAcademic/Hospital2112021
66 organizations
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