← Mechanisms of action
RET
SINGLE PROTEINHomo sapiens
Preferred name: Tyrosine-protein kinase receptor RET ChEMBL ↗
Linked proteins
Drugs acting on this target (21)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| aps03118 | Antagonist | experimental | Small molecule | RET |
| ep0031 | Antagonist | experimental | Small molecule | RET |
| hec169096 | Antagonist | experimental | Small molecule | RET |
| kl590586 | Antagonist | experimental | Small molecule | RET |
| loxo-260 | Antagonist | experimental | Small molecule | RET |
| sy-5007 | Antagonist | experimental | Small molecule | RET |
| alectinib (alecensa) | Inhibitor | approved | Small molecule | RET inhibitor |
| blu-667 | Inhibitor | experimental | Small molecule | RET inhibitor |
| cep-32496 | Inhibitor | experimental | Small molecule | RET inhibitor |
| cep2563 | Inhibitor | experimental | Small molecule | RET inhibitor |
| gsk3352589 | Inhibitor | experimental | Small molecule | Tyrosine-protein kinase receptor RET inhibitor |
| hs-10365 | Inhibitor | experimental | Small molecule | inhibitor - RET |
| lestaurtinib | Inhibitor | experimental | Small molecule | RET inhibitor |
| nvp-ast487 | Inhibitor | experimental | Small molecule | RET inhibitor |
| pralsetinib (Gavreto) | Inhibitor | approved | Small molecule | Tyrosine-protein kinase receptor RET inhibitor |
| quizartinib (VANFLYTA) | Inhibitor | approved | Small molecule | RET inhibitor |
| regorafenib (stivarga) | Inhibitor | approved | Small molecule | RET inhibitor |
| Selpercatinib (Retevmo) | Inhibitor | approved | Small molecule | Tyrosine-protein kinase receptor RET inhibitor |
| sorafenib (nexavar) | Inhibitor | approved | Small molecule | RET inhibitor |
| sunitinib (sutent) | Inhibitor | approved | Small molecule | RET inhibitor |
| vandetanib (caprelsa) | Inhibitor | approved | Small molecule | RET inhibitor |