← Mechanisms of action
KLKB1
SINGLE PROTEINHomo sapiens
Preferred name: Plasma kallikrein ChEMBL ↗
Linked proteins
Drugs acting on this target (11)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| berotralstat (Orladeyo) | Antagonist | approved | Small molecule | KLKB1 antagonist |
| adx-324 | Antisense inhibitor | experimental | Nucleic acid | KLKB1 antisense inhibitor |
| donidalorsen | Antisense inhibitor | approved | Nucleic acid | KLKB1 antisense inhibitor |
| ionis-pkkrx | Antisense inhibitor | experimental | Nucleic acid | KLKB1 antisense inhibitor |
| aprotinin (trasylol) | Inhibitor | withdrawn | Small molecule | KLKB1 inhibitor |
| avoralstat | Inhibitor | experimental | Small molecule | Plasma kallikrein inhibitor |
| berotralstat (Orladeyo) | Inhibitor | approved | Small molecule | Plasma kallikrein inhibitor |
| C1 Esterase Inhibitor (Human) (Cinryze) | Inhibitor | approved | Recombinant protein | Plasma kallikrein inhibitor |
| ecallantide (Kalbitor) | Inhibitor | approved | Peptide | KLKB1 inhibitor |
| lanadelumab (takhzyro) | Inhibitor | approved | mAb | KLKB1 inhibitor |
| ntla-2002 | Supplementation | experimental | Gene therapy | KLKB1 supplementation |