avoralstat
Small moleculeexperimental
Clinical trial activity
5 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
2
Phase 3
2
Phase 4
0
Earliest trial started Nov 1, 2013 (NCT01984788)
Timeline
Indications
Studied for
Mechanism of action
- Kallikrein 1INHIBITOR
KLK1 inhibitor
- Plasma kallikreinINHIBITOR
Plasma kallikrein inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C=Cc1cc(C(=O)Nc2ccc(C(=N)N)cc2)c(-c2ccc(C(=O)NCC3CC3)nc2C(=O)O)cc1OC- Mol. weight
- 513.55 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297502 ↗
Also known as
- avoralstat
- avoralstat
- avoralstat
- bcx4161
- bcx4161
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02670720 | Phase 3 | Dec 1, 2015 | BioCryst, Semmelweis University |
| NCT02303626 | Phase 2/Phase 3 (Phase 3) | Nov 1, 2014 | BioCryst, University of California, San Diego |
| NCT02218294 | Phase 1 | Aug 1, 2014 | BioCryst, Quotient |
| NCT02125162 | Phase 1 | Apr 1, 2014 | BioCryst, Quotient |
| NCT01984788 | Phase 2 | Nov 1, 2013 | BioCryst, Humboldt University |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BioCryst | For profit | 5 | 5 | 3 | 2013 |
| Quotient | For profit | 2 | 0 | 1 | 2014 |
| Humboldt University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Semmelweis University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of California, San Diego | Academic/Hospital | 1 | 0 | 1 | 2014 |
5 organizations
Page 1 / 1