← Mechanisms of action
PI3-kinase class I
PROTEIN COMPLEX GROUPHomo sapiens
Linked proteins
- Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) ↗
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) ↗
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG) ↗
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) ↗
- Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) ↗
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) ↗
- Phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5) ↗
- Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) ↗
Drugs acting on this target (28)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| apitolisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| azd6482 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| buparlisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| ch-5132799 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| copanlisib (aliqopa) | Inhibitor | approved | Small molecule | PI3-kinase class I inhibitor |
| dactolisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| ds-7423 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| gdc-0084 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| gedatolisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| gsk-1059615 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| ly-3023414 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| ly3023414 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| nvp-bgt226 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| omipalisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| panulisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| pf-04691502 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| pictilisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| pilaralisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| puquitinib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| pwt-33587 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| recilisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| sf1126 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| sonolisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| taselisib | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| vs-5584 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| wx-037 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| xl765 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |
| zstk-474 | Inhibitor | experimental | Small molecule | PI3-kinase class I inhibitor |