lactobacillus brevis
Levilactobacillus brevis is a gram-positive, rod shaped species of lactic acid bacteria which is heterofermentative, creating CO2, lactic acid and acetic acid or ethanol during fermentation. L. brevis is the type species of the genus Levilactobacillus (previously L. brevis group), which comprises 24 species. It can be found in many different environments, such as fermented foods, and as normal microbiota. L. brevis is found in food such as sauerkraut and pickles. It is also one of the most common causes of beer spoilage. Ingestion has been shown to improve human immune function, and it has been patented several times. Normal gut microbiota L. brevis is found in human intestines, vagina, and feces. — Wikipedia
Clinical trial activity
20 trials · 32 clinical orgs · 0 marketing orgs
Earliest trial started Feb 1, 2006 (NCT00587041)
Timeline
Indications
Approved for
Studied for
- Bacterial Infections · Phase 2
- Body Weight · Phase 3
- Chronic Periodontitis · Phase 3
- Coronavirus Infections · Phase 2
- COVID-19 · Phase 2
- Crohn Disease · Phase 1/Phase 2
- Dental Caries · Phase 4
- Gingivitis · Phase 4
- Head and Neck Neoplasms · Phase 3
- Hyperoxaluria · Phase 1/Phase 2
- Malocclusion · Phase 3
- Mucositis · Phase 4
- Nephrolithiasis · Phase 1/Phase 2
- Pain · Phase 3
- Periodontitis · Phase 3
- Pneumonia, Viral · Phase 2
- Radiation Oncology · Phase 3
- Stomatitis · Phase 2
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLevilactobacillus brevis ↗
- WikipediaLactobacillus brevis ↗
Also known as
- inersan
- lactobacillus brevis
- lactobacillus brevis cd2
- l. brevis
- l. brevis cd2
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04823676 | N/A | Mar 31, 2021 | AB Biotics, SA |
| NCT04366089 | Phase 2 | Mar 26, 2020 | University of Roma La Sapienza |
| NCT03959722 | N/A | Oct 31, 2019 | Hogeschool Leiden, University of Applied Sciences, Leiden University, University of Amsterdam, Wageningen University, Winclove Bio Industries BV |
| NCT04398511 | Phase 2 | Jan 7, 2019 | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Universidade de Passo Fundo |
| NCT04089280 | N/A | Oct 16, 2018 | Sanprobi Sp. z o.o., Silesian University of Medicine |
| NCT03540498 | N/A | Oct 13, 2016 | AB Biotics, SA, University of Barcelona |
| NCT04203771 | N/A | Jun 30, 2016 | AB Biotics, SA, University of Barcelona |
| NCT02357771 | Phase 3 | Apr 1, 2015 | Next Gen Pharma India Pvt. Ltd., Peoples College of Dental Sciences & Research Centre, Bhanpur, Bhopal, Madya Pradesh, Peoples University, Bhanpur, Bhopal |
| NCT02329353 | Phase 3 | Feb 1, 2015 | Krishnadevaraya College of Dental Sciences & Hospital, Next Gen Pharma India Pvt. Ltd. |
| NCT02203812 | Phase 3 | Jan 1, 2015 | CD Pharma India Pvt. Ltd., Government Dental College and Hospital, Vijayawada, Andhra Pradesh |
| NCT02174757 | Phase 3 | Aug 1, 2014 | CD Pharma India Pvt. Ltd., Sree Mookambika Institute of Dental Sciences |
| NCT02121665 | Phase 3 | Jul 1, 2014 | CD Pharma India Pvt. Ltd., Government Dental College & Hospital, Aurangabad |
| NCT02085694 | Phase 2/Phase 3 (Phase 3) | Mar 1, 2014 | Catholic University of Sacred Heart, Rome |
| NCT01870362 | Phase 3 | Jun 1, 2013 | CD Pharma India Pvt. Ltd., Mahatma Gandhi Post-Graduate Institute of Dental Sciences |
| NCT01778699 | Phase 4 | Feb 1, 2013 | University of Gothenburg, University of Milan, University of Sassari |
| NCT01782079 | N/A | Jan 1, 2013 | University of Roma La Sapienza |
| NCT01707641 | Phase 4 | Nov 1, 2012 | University of Roma La Sapienza |
| NCT01545687 | Phase 3 | Apr 1, 2012 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT01438333 | N/A | Sep 1, 2011 | University of L'Aquila |
| NCT00587041 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2006 | Mayo Clinic, National Center for Complementary and Integrative Health (NCCIH), National Center for Research Resources (NCRR), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH) |