nandrolone phenpropionate

Trade name: Durabolin

Small moleculeapproved

Approved

Oct 30, 1959

Nandrolone phenylpropionate (NPP), or nandrolone phenpropionate, sold under the brand name Durabolin among others, is an androgen and anabolic steroid (AAS) medication which has been used primarily in the treatment of breast cancer and osteoporosis in women. It is given by injection into muscle once every week. Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly no longer available. — Wikipedia

Clinical trial activity

14 trials · 17 clinical orgs · 10 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Mar 1, 1982 (NCT00000597)

Timeline

1950s

Oct 30, 1959
Organon — Earliest FDA Approval
Oct 30, 1959
Organon — NDA Organization

1960s

Oct 5, 1962
Aspen Pharmaceuticals — NDA Secondary Org
Oct 5, 1962
Woodward — Marketing Organization
Oct 5, 1962
Woodward — NDA Secondary Org

1980s

Jan 1, 1982
Earliest Phase 3 Sponsor(trial)
May 17, 1983
Watson Pharmaceuticals — Marketing Organization
Oct 14, 1983
Abraxis — Marketing Organization

1990s

Jan 1, 1999
Earliest Phase 1 Sponsor(trial)

2000s

Jan 1, 2005
Earliest Phase 2 Sponsor(trial)

2010s

Aug 30, 2010
Sankyo — Marketing Organization
Aug 30, 2010
Lutipold — Marketing Organization
Aug 30, 2010
Daiichi Sankyo — Marketing Organization

Indications

Approved for

Anemia (approved 1959)

Studied for

Mechanism of action

Androgen ReceptorAGONIST
AR agonist
- Androgen receptor (AR) ↗

Approval history

approvedOct 30, 1959

Chemistry & pharmacology

Loading structure…

SMILES

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@H]2OC(=O)CCc1ccccc1

Mol. weight: 406.57 g/mol
Lipinski Ro5: 1 violation(s)
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Discontinued

Oral

Parenteral

Yes

Topical

Prodrug

Sources

Also known as

17 beta-hydroxyestr-4-en-3-one 17-decanoate
17 beta-hydroxyestr-4-en-3-one hydrocinnamate
17-hydroxyestr-4-en-3-one
17-hydroxyestr-4-en-3-one
19-nor-4-androstene-17 beta-ol-3-one 17-decanoate
19-norandrostendione
19-nortestosterone
19-nortestosterone
19-nortestosterone
19-nortestosterone decanoate
19-nortestosterone decanoate
19-nortestosterone decanoate
19ntpp
19ntpp
decadurabolin
deca-durabolin
deca-durabolin
deca-durabolin
decadurobolin
durabolin
durabolin
durabolin
durabolin
durabolin
durabolin
fenobolin
hybolin decanoate
menidrabol
nadrolone phenylpropionate
nadrolone phenylpropionate
nandrolon
nandrolone
nandrolone
nandrolone
nandrolone
nandrolone
nandrolone
nandrolone
nandrolone
nandrolone
nandrolone 17β-decanoate
nandrolone 17β-decanoate
nandrolone ciii
nandrolone ciii
nandrolone decanoate
nandrolone decanoate
nandrolone decanoate
nandrolone decanoate
nandrolone decanoate
nandrolone decanoate
nandrolone decanoate
nandrolone decanoate
nandrolone decanoate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate
nandrolone phenpropionate, (17alpha)-isomer
nandrolone phenylpionate
nandrolone phenylpionate
nandrolone phenylpropionate
nandrolone phenylpropionate
nandrolone phenylpropionate
nandrolone phenylpropionate
nandrolon phenylpropionate
nandrolon phenylpropionate
nandrolon phenylpropionate
nerobolil
nerobolyl
norandrolone phenylpropionate
norandrolone phenylpropionate
norandrolone phenyl propionate
norandrolone phenyl propionate
norandrostenolon
norandrostenolone
norandrostenolone
norandrostenolone
norandrostenolone decanoate
norandrostenolone phenylpropionate
norandrostenolone phenylpropionate
norandrostenolone phenylpropionate
norandrostenolone phenylpropionate
nortestonate
nortestosterone
nortestosterone decanoate
nortestosterone furanpropionate
nortestosterone furanpropionate
nortestosterone phenylpropionate
nortestosterone phenylpropionate
nortestosterone phenylpropionate
nortestosterone phenylpropionate
nortestosterone phenylpropionate
npp
npp
nsc-23162e
ntpp
ntpp
oestrenolon
retabolil
retabolyl

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT06608914	Phase 4	Nov 30, 2024	American Hip Institute
NCT06462482	Phase 4	Aug 31, 2024	American Hip Institute
NCT05978206	Phase 2	Aug 10, 2023	Government of Poland
NCT05805553	N/A	Dec 1, 2020	King Edward Medical University
NCT03576001	Phase 2	Jan 31, 2019	Harvard University, National Institutes of Health (NIH)
NCT03545347	Phase 2	Sep 3, 2018	Amager Hospital, University of Copenhagen
NCT03263520	N/A	Feb 29, 2016	Hospital Erasto Gaertner
NCT02376309	N/A	Aug 1, 2015	Maastricht University
NCT02055456	Phase 1/Phase 2 (Phase 2)	Feb 1, 2014	Conselho Nacional de Desenvolvimento Científico e Tecnológico, University of Sao Paulo
NCT00682123	Phase 1/Phase 2 (Phase 2)	Mar 1, 2006	Loughborough University
NCT00242463	Phase 2	Oct 1, 2005	University of Western Ontario
NCT00250536	N/A	Mar 1, 2000	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of California, San Francisco
NCT00000854	Phase 1	Nov 2, 1999	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00000597	Phase 3	Mar 1, 1982	National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)

Showing 14 of 14 trials

Page 1 / 1

Organizations

Research & Development (17)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
American Hip Institute	Academic/Hospital	2	2	1	2024
National Institutes of Health (NIH)	Government	2	0	2	1982
Amager Hospital	Academic/Hospital	1	0	1	2018
Conselho Nacional de Desenvolvimento Científico e Tecnológico	Government	1	0	1	2014
Government of Poland	Government	1	1	1	2023
Harvard University	Academic/Hospital	1	1	1	2019
Hospital Erasto Gaertner	Academic/Hospital	1	1	1	2016
King Edward Medical University	Academic/Hospital	1	1	1	2020
Loughborough University	Academic/Hospital	1	1	1	2006
Maastricht University	Academic/Hospital	1	1	1	2015
National Heart, Lung, and Blood Institute (NHLBI)	Government	1	1	1	1982
National Institute of Allergy and Infectious Diseases (NIAID)	Government	1	1	1	1999
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Government	1	1	1	2000
University of California, San Francisco	Academic/Hospital	1	0	1	2000
University of Copenhagen	Academic/Hospital	1	1	1	2018
University of Sao Paulo	Academic/Hospital	1	1	1	2014
University of Western Ontario	Academic/Hospital	1	1	1	2005

17 organizations

Page 1 / 1

Marketing (11)

Organization	Org type	Relationship	Date
Abraxis	For profit	MKTG	Oct 14, 1983
Akorn, Inc.	For profit	MKTG	—
Aspen Pharmaceuticals	For profit	NDA2	Oct 5, 1962
Athenex, Inc.	For profit	MKTG	—
Daiichi Sankyo	For profit	MKTG	Aug 30, 2010
Lutipold	For profit	MKTG	Aug 30, 2010
Organon	For profit	NDA	Oct 30, 1959
Sankyo	For profit	MKTG	Aug 30, 2010
Watson Pharmaceuticals	For profit	MKTG	May 17, 1983
Woodward	For profit	MKTG	Oct 5, 1962
Woodward	For profit	NDA2	Oct 5, 1962