zucapsaicin

Small moleculeexperimental

Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. Zucapsaicin is a member of phenols and a member of methoxybenzenes. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1 that reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use. — Wikipedia

Clinical trial activity

10 trials · 2 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Jan 1, 2002 (NCT00033839)

Timeline

2000s

Jan 1, 2002
Earliest Phase 3 Sponsor(trial)
Jan 1, 2008
Earliest Phase 1 Sponsor(trial)
Jan 1, 2009
Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

Vanilloid receptorAGONIST
TRPV1 agonist
- Transient receptor potential cation channel subfamily V member 1 (TRPV1) ↗

Chemistry & pharmacology

Loading structure…

SMILES

COc1cc(CNC(=O)CCCC/C=C\C(C)C)ccc1O

Mol. weight: 305.42 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Sources

WikipediaZucapsaicin ↗
ChEMBLCHEMBL313971 ↗

Also known as

cis-capsaicin
cis-capsaicin
cis-capsaicin
civamide
civamide
civamide
civamide
civamide
(z)-capsaicin
(z)-capsaicin
(z)-capsaicin
zucapsaicin
zucapsaicin
zucapsaicin
zucapsaicin
zucapsaicin
zucapsaicin
zucapsaicin
zucapsaicin

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT01341548	Phase 3	Nov 1, 2017	Winston Laboratories
NCT02116244	Phase 2	May 1, 2014	Winston Laboratories
NCT01886313	Phase 2	Mar 1, 2014	Winston Laboratories
NCT00845923	Phase 2	Mar 1, 2009	Winston Laboratories
NCT00802217	Phase 1	Nov 1, 2008	Parexel, Winston Laboratories
NCT00758433	Phase 1	Sep 1, 2008	Winston Laboratories
NCT00077935	Phase 3	Nov 1, 2003	Winston Laboratories
NCT00069082	Phase 3	Aug 1, 2003	Winston Laboratories
NCT00995306	Phase 3	Jun 1, 2003	Winston Laboratories
NCT00033839	Phase 3	Jan 1, 2002	Winston Laboratories

Showing 10 of 10 trials

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Organizations

Research & Development (2)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Winston Laboratories	For profit	10	10	3	2002
Parexel	For profit	1	0	1	2008

2 organizations

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