endotoxin

Biologicalexperimental

Lipopolysaccharide (LPS), now more commonly known as endotoxin, is a collective term for components of the outermost membrane of the cell envelope of gram-negative bacteria, such as E. coli and Salmonella with a common structural architecture. Lipopolysaccharides are large molecules consisting of three parts: an outer core polysaccharide termed the O-antigen, an inner core oligosaccharide and Lipid A, all covalently linked. In current terminology, the term endotoxin is often used synonymously with LPS, although there are a few endotoxins that are not related to LPS, such as the so-called delta endotoxin proteins produced by Bacillus thuringiensis. — Wikipedia

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • endotoxin
  • endotoxin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06665074Phase 2Jan 31, 2025National Institute of Mental Health (NIMH), Ohio State University
NCT05363527Phase 1Oct 31, 2022National Institute on Aging (NIA), University of California, Los Angeles
NCT04527185Phase 2Feb 1, 2021National Institute on Alcohol Abuse and Alcoholism (NIAAA), Yale University
NCT04310423Phase 2Apr 30, 2020University of California, Los Angeles
NCT06801873N/AMay 27, 2019Radboud University
NCT03848715Phase 1Apr 30, 2019University of California, Los Angeles
NCT03256760Phase 1Jan 1, 2018University of California, Los Angeles
NCT03083171Phase 1Jan 4, 2017Adrenomed AG, Radboud University
NCT02847247Phase 1Dec 1, 2016Environmental Protection Agency, University of North Carolina at Chapel Hill
NCT02789241Phase 1Aug 1, 2016Duke University, National Institutes of Health (NIH)
NCT02392442Phase 2Feb 25, 2015National Institutes of Health (NIH)
NCT02529592N/AFeb 1, 2015Danderyds Hospital, Karolinska Institute
NCT02629874Phase 1Feb 1, 2015Exponential Biotherapies Inc., Radboud University
NCT02270619Early Phase 1 (Phase 1)Oct 1, 2014University of California, Los Angeles
NCT02127749N/AJun 1, 2014University of Amsterdam
NCT02151552Early Phase 1 (Phase 1)May 1, 2014Doris Duke Charitable Foundation, Washington University in St. Louis
NCT01766414Phase 3Sep 1, 2013Radboud University, Sanquin, Utrecht University
NCT01846559Phase 4Apr 1, 2013Sheffield Hallam University
NCT01592526Early Phase 1 (Phase 1)Jun 30, 2012University of Copenhagen
NCT00753402Phase 1Feb 1, 2012Rutgers University
Showing 20 of 51 trials
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Organizations

Research & Development (39)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Radboud UniversityAcademic/Hospital9832003
University of North Carolina at Chapel HillAcademic/Hospital8812002
National Institutes of Health (NIH)Government7321992
University of California, Los AngelesAcademic/Hospital7722007
National Heart, Lung, and Blood Institute (NHLBI)Government3022002
Rutgers UniversityAcademic/Hospital3312000
Washington University in St. LouisAcademic/Hospital3312007
Aarhus UniversityAcademic/Hospital2212009
Duke UniversityAcademic/Hospital2212007
Karolinska InstituteAcademic/Hospital2212010
MallinckrodtFor profit2212007
National Institute of Environmental Health Sciences (NIEHS)Government2012003
National Institute of Mental Health (NIMH)Government2022011
University of AmsterdamAcademic/Hospital2212008
University of PennsylvaniaAcademic/Hospital2212003
ZonMw: The Netherlands Organisation for Health Research and DevelopmentAcademic/Hospital2022003
Adrenomed AGFor profit1112017
Boehringer IngelheimFor profit1112010
Danderyds HospitalAcademic/Hospital1012015
Doris Duke Charitable FoundationAcademic/Hospital1012014
39 organizations
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