funapide
Small moleculeexperimental
Funapide is a novel analgesic under development by Xenon Pharmaceuticals for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain. It acts as a small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker. Funapide was evaluated in humans in both oral and topical formulations, and as of July 2014, had reached phase IIb clinical trials. Development of the drug was discontinued in 2022. — Wikipedia
Clinical trial activity
6 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Aug 1, 2010 (NCT01195636)
Timeline
Indications
Mechanism of action
SCN10A blocker
SCN9A blocker
Chemistry & pharmacology
Loading structure…
SMILES
O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2[C@]12COc1cc3c(cc12)OCO3- Mol. weight
- 429.35 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaFunapide ↗
- ChEMBLCHEMBL3707218 ↗
Also known as
- funapide
- funapide
- funapide
- tv-45070
- tv-45070
- tv-45070
- xen-401-s
- xen-401-s
- xen-402
- xen-402
- xpf-002
- xpf-002
- xpf-002
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04826328 | Phase 1 | Mar 15, 2021 | Flexion Therapeutics, Lotus Clinical Research |
| NCT02365636 | Phase 2 | Feb 28, 2015 | Teva |
| NCT02215941 | Phase 1 | Aug 1, 2014 | Teva |
| NCT02068599 | Phase 2 | Feb 1, 2014 | Teva |
| NCT01486446 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2011 | Pinnacle Research Group, Xenon Pharmaceuticals Inc. |
| NCT01195636 | Phase 2 | Aug 1, 2010 | Xenon Pharmaceuticals Inc. |
Showing 6 of 6 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Teva | For profit | 3 | 3 | 2 | 2014 |
| Xenon Pharmaceuticals Inc. | For profit | 2 | 2 | 1 | 2010 |
| Flexion Therapeutics | For profit | 1 | 1 | 1 | 2021 |
| Lotus Clinical Research | For profit | 1 | 0 | 1 | 2021 |
| Pinnacle Research Group | For profit | 1 | 0 | 1 | 2011 |
5 organizations
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