tropisetron
Small moleculeexperimental
Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. — Wikipedia
Clinical trial activity
21 trials · 26 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
7
Phase 3
4
Phase 4
8
Earliest trial started Oct 1, 1999 (NCT00003817)
Timeline
Indications
Approved for
Studied for
- Antiemetics · Phase 3
- Chronic Disease · Phase 2
- Colorectal Neoplasms · Phase 3
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Emergence Delirium · Phase 4
- Liver Neoplasms · Phase 2
- Nasopharyngeal Neoplasms · Phase 3
- Nausea · Phase 4
- Neoplasms · Phase 2
- Pain · Phase 4
- Postoperative Cognitive Complications · Phase 4
- Postoperative Complications · Phase 4
- Postoperative Nausea and Vomiting · Phase 4
- Postoperative Pain · Phase 4
- Radiation · Phase 3
- Schizophrenia · Phase 3
- Smoking Cessation · Phase 3
- Uterine Cervical Neoplasms · Phase 3
- Vomiting · Phase 4
Mechanism of action
- Serotonin 3 (5-HT3) receptorANTAGONIST
Serotonin 3 (5-HT3) receptor antagonist
- Serotonin 3a (5-HT3a) receptorINHIBITOR
HTR3A inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)c1c[nH]c3ccccc13)C2- Mol. weight
- 284.36 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTropisetron ↗
- ChEMBLCHEMBL56564 ↗
Also known as
- 1h-indole-3-carboxylic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-
- (3 alpha-tropanyl)-1h-indole-3-carboxylic acid ester
- ics 205-930
- ics-205930
- ics-205-930
- ics-205-930
- ics-205-930
- indole-3-carboxylic acid tropine ester
- navoban
- navoban
- navoban
- navoban
- novartis brand of tropisetron hydrochloride
- tropisetron
- tropisetron
- tropisetron
- tropisetron
- tropisetron
- tropisetron
- tropisetron
- tropisetron
- tropisetron hcl
- tropisetron hydrochloride
- tropisetron hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05533281 | Early Phase 1 (Phase 1) | Sep 15, 2022 | Chongqing Medical University |
| NCT05331651 | Phase 4 | Apr 8, 2022 | Chongqing Medical University, Ninth People's Hospital of Chongqing, People's Liberation Army of China, The People's Hospital of Nanchuan |
| NCT05242874 | Phase 3 | Jan 1, 2022 | Henan Medical University |
| NCT05564286 | Phase 3 | Jul 1, 2021 | Shantou University |
| NCT04817189 | Phase 4 | Feb 1, 2021 | Helsinn, The Hong Kong Polytechnic University |
| NCT04195204 | Phase 4 | Dec 31, 2019 | Capital Medical University |
| NCT04027751 | Phase 4 | Aug 1, 2019 | Capital Medical University |
| NCT03540537 | N/A | Jul 1, 2018 | Southern Medical University |
| NCT02909478 | Phase 3 | Dec 1, 2016 | Sun Yat-Sen University |
| NCT02625181 | N/A | Jul 1, 2016 | University of Washington, Vanderbilt University |
| NCT02576327 | Phase 4 | Oct 1, 2015 | Peking University |
| NCT02478047 | N/A | Jun 1, 2015 | National Basic Research Program, China, Tianjin University of Traditional Chinese Medicine |
| NCT02096835 | N/A | Jan 1, 2014 | Fudan University |
| NCT01895010 | Phase 2 | Jun 1, 2013 | Fudan University |
| NCT01636947 | Phase 4 | Dec 12, 2012 | Merck |
| NCT01304953 | Phase 4 | Jan 1, 2010 | Huazhong University of Science and Technology |
| NCT00970450 | N/A | Nov 1, 2009 | University of Bern |
| NCT00889499 | Phase 2 | Mar 1, 2009 | University of Bern |
| NCT00487110 | Phase 4 | Jun 1, 2008 | University Clermont Auvergne |
| NCT00435370 | Phase 3 | Nov 1, 2006 | Baylor University, National Institute of Mental Health (NIMH) |
Showing 20 of 21 trials
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Organizations
Research & Development (26)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Capital Medical University | Academic/Hospital | 2 | 2 | 1 | 2019 |
| Chongqing Medical University | Academic/Hospital | 2 | 2 | 2 | 2022 |
| Fudan University | Academic/Hospital | 2 | 2 | 2 | 2013 |
| University of Bern | Academic/Hospital | 2 | 2 | 2 | 2009 |
| Baylor University | Academic/Hospital | 1 | 1 | 1 | 2006 |
| Helsinn | For profit | 1 | 1 | 1 | 2021 |
| Henan Medical University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Merck | For profit | 1 | 1 | 1 | 2012 |
| National Basic Research Program, China | Academic/Hospital | 1 | 0 | 1 | 2015 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 1999 |
| National Institute of Mental Health (NIMH) | Government | 1 | 0 | 1 | 2006 |
| New York University | Academic/Hospital | 1 | 0 | 1 | 1999 |
| Ninth People's Hospital of Chongqing | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Peking University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| People's Liberation Army of China | Government | 1 | 0 | 1 | 2022 |
| Shantou University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Southern Medical University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| The Hong Kong Polytechnic University | Academic/Hospital | 1 | 0 | 1 | 2021 |
26 organizations
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