CDEK
← All drugs Report issue

sch66336

Small moleculeexperimental

Clinical trial activity

36 trials · 25 clinical orgs · 0 marketing orgs

Phase 1
17
Phase 2
22
Phase 3
2
Phase 4
0

Earliest trial started Oct 1, 1998 (NCT00020774)

Timeline

1990s

  1. Jan 1, 1998

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

2000s

  1. Jan 1, 2002

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

NC(=O)N1CCC(CC(=O)N2CCC([C@H]3c4ncc(Br)cc4CCc4cc(Cl)cc(Br)c43)CC2)CC1
Mol. weight
638.83 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Prescription Only

Oral

Yes

Parenteral

No

Topical

No

First in class

Sources

Also known as

  • 1-piperidinecarboxamide, 4(2-(4-(11r-3,10-dibromo-8-chloro-6,11-dihydro-5h-benzo(5,6)cyclohepta(1,2-b)pyridine-11-yl)-1-piperidinyl)-2-oxoethyl)-
  • 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5h-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(r)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide
  • (+)4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5h-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide
  • lonafarnib
  • lonafarnib
  • lonafarnib
  • lonafarnib
  • sch66336
  • sch66336
  • sch66336
  • sch 66336
  • sch 66336
  • sch 66336
  • sch-66336
  • sch-66336

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT02968641Phase 2Mar 1, 2017Eiger BioPharmaceuticals
NCT02579044Phase 1/Phase 2 (Phase 2)Dec 1, 2015Harvard University
NCT02527707Phase 2Sep 1, 2015Eiger BioPharmaceuticals, Gottfried Wilhelm Leibniz Universität Hannover
NCT02511431Phase 2Jul 21, 2015National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02430194Phase 2Dec 1, 2014Eiger BioPharmaceuticals, University of Ankara
NCT02430181Phase 2Nov 1, 2014Eiger BioPharmaceuticals, University of Ankara
NCT01495585Phase 2Dec 1, 2011National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00916747Phase 2Aug 1, 2009Harvard University, Schering-Plough
NCT00879034Phase 2Mar 1, 2009Harvard University, Schering-Plough
NCT00773474Phase 2Oct 1, 2008Hoosier Cancer Research Network, Indiana University, Schering-Plough
NCT00539968Phase 1/Phase 2 (Phase 2)Jun 1, 2007Merck
NCT00425607Phase 2May 1, 2007Boston University, Harvard University, Schering-Plough
NCT00281515Phase 2Jan 1, 2006AGO Germany
NCT00288444Phase 1Jan 1, 2006Aventis, Emory University, Schering-Plough
NCT00612651Phase 1Oct 1, 2005Duke University, Schering-Plough
NCT00109538Phase 3May 1, 2005Merck
NCT00102635Phase 1Jan 1, 2005National Cancer Institute (NCI), Schering-Plough, University of Texas at Houston
NCT00103090Phase 1Jan 1, 2005National Cancer Institute (NCI), University of Texas at Houston
NCT00102648Phase 1Dec 1, 2004Schering-Plough, University of Texas at Houston
NCT00083096Phase 1Mar 1, 2004European Organisation for Research and Treatment of Cancer, Institut de Cancerologie de l'Ouest Paul Papin
Showing 20 of 36 trials
Page 1 / 2

Organizations

Research & Development (25)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Schering-PloughFor profit9021999
MerckFor profit8832001
University of Texas at HoustonAcademic/Hospital8821999
National Cancer Institute (NCI)Government6021998
Harvard UniversityAcademic/Hospital5322002
Eiger BioPharmaceuticalsFor profit4412014
European Organisation for Research and Treatment of CancerAcademic/Hospital3322000
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government2212011
University of AnkaraAcademic/Hospital2012014
AGO GermanyAcademic/Hospital1112006
AventisFor profit1012006
Boston UniversityAcademic/Hospital1112007
Cornell UniversityAcademic/Hospital1111999
Duke UniversityAcademic/Hospital1112005
Emory UniversityAcademic/Hospital1112006
Erasmus University RotterdamAcademic/Hospital1012000
Gottfried Wilhelm Leibniz Universität HannoverAcademic/Hospital1012015
Hoosier Cancer Research NetworkAcademic/Hospital1012008
Indiana UniversityAcademic/Hospital1112008
Institut de Cancerologie de l'Ouest Paul PapinAcademic/Hospital1012004
25 organizations
Page 1 / 2