s-licarbazepine
Small moleculeexperimental
Clinical trial activity
9 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
5
Phase 3
5
Phase 4
1
Earliest trial started Oct 1, 2004 (NCT00107926)
Timeline
Indications
Approved for
Mechanism of action
- Voltage-gated calcium channelANTAGONIST
Voltage-gated calcium channel antagonist
- Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D) ↗
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) ↗
- Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B) ↗
- Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-4 (CACNA2D4) ↗
- Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F) ↗
- Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E) ↗
- Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) ↗
- Voltage-dependent calcium channel gamma-7 subunit (CACNG7) ↗
- Voltage-dependent calcium channel gamma-5 subunit (CACNG5) ↗
- Voltage-dependent calcium channel gamma-2 subunit (CACNG2) ↗
- Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) ↗
- Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) ↗
- Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) ↗
- Voltage-dependent calcium channel gamma-4 subunit (CACNG4) ↗
- Voltage-dependent calcium channel gamma-8 subunit (CACNG8) ↗
- Voltage-dependent calcium channel gamma-3 subunit (CACNG3) ↗
- Voltage-dependent calcium channel gamma-6 subunit (CACNG6) ↗
- Voltage-dependent calcium channel gamma-1 subunit (CACNG1) ↗
- Voltage-gated T-type calcium channel alpha-1H subunit
- Voltage-gated calcium channel alpha2/delta subunit 1
- Voltage-gated L-type calcium channel alpha-1C subunit
- Voltage-gated N-type calcium channel alpha-1B subunit
- Voltage-gated L-type calcium channel alpha-1S subunit
- Voltage-gated L-type calcium channel alpha-1D subunit
- Voltage-gated calcium channel alpha2/delta subunit 2
- Voltage-gated P/Q-type calcium channel alpha-1A subunit
- Voltage-gated T-type calcium channel alpha-1G subunit
- Voltage-gated T-type calcium channel alpha-1I subunit
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Voltage-gated L-type calcium channel
- Voltage-gated T-type calcium channel
- Voltage-dependent L-type calcium channel subunit beta-2
- Voltage-dependent N-type calcium channel subunit alpha-1B/Voltage-dependent calcium channel subunit alpha-2/delta-1/Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b
- Voltage-dependent P/Q-type calcium channel alpha1A/alpha2delta/beta1b
- N-type calcium channel alpha-1b/alpha2delta-1/beta-1b
- L-type calcium channel alpha-1c/beta-2/alpha2delta-1
- Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel subunit alpha-1C/L-type calcium channel subunit beta-3/calcium channel subunit alpha-2/delta-1
Chemistry & pharmacology
Loading structure…
SMILES
NC(=O)N1c2ccccc2CC(O)c2ccccc21- Mol. weight
- 254.29 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1067 ↗
Also known as
- 10,11-dihydro-10-hydroxy-5h-dibenz(b,f)azepine-5-carboxamide
- 10,11-mhd
- 10-hydroxy-carbamazepine
- 10-hydroxy-carbamazepine
- licarbazepine
- licarbazepine
- licarbazepine
- licarbazepine
- s-licarbazepine
- s-licarbazepine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00424671 | Phase 1 | Nov 1, 2006 | Novartis |
| NCT02281591 | Phase 1 | Jun 1, 2006 | Bial |
| NCT00426036 | Phase 1 | Jun 1, 2006 | Novartis |
| NCT00228059 | Phase 3 | Jan 1, 2005 | Novartis |
| NCT00238485 | Phase 3 | Jan 1, 2005 | Novartis |
| NCT00139594 | Phase 4 | Dec 1, 2004 | Novartis |
| NCT00107939 | Phase 3 | Nov 1, 2004 | Novartis |
| NCT00099229 | Phase 3 | Nov 1, 2004 | Novartis |
| NCT00107926 | Phase 3 | Oct 1, 2004 | Novartis |
Showing 9 of 9 trials
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