alfacalcidol
Small moleculeexperimental
Alfacalcidol is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive. — Wikipedia
Clinical trial activity
35 trials · 37 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
11
Phase 3
6
Phase 4
15
Earliest trial started Jan 1, 2002 (NCT00175149)
Timeline
Indications
Approved for
Studied for
- Accidental Falls · Phase 4
- Aged · Phase 4
- Arthritis, Rheumatoid · Phase 4
- Asthma · Phase 4
- Bone Diseases, Metabolic · Phase 4
- Cardiovascular Diseases · Phase 2
- Death, Sudden, Cardiac · Phase 2
- Diabetes Mellitus · Phase 4
- Frail Elderly · Phase 4
- Geriatrics · Phase 4
- Graves Disease · Phase 2
- Heart Valve Diseases · Phase 4
- Hepatitis C, Chronic · Phase 4
- Hyperparathyroidism, Secondary · Phase 4
- Hypertrophy, Left Ventricular · Phase 4
- Hypoparathyroidism · Phase 2
- Kidney Failure, Chronic · Phase 4
- Lupus Erythematosus, Systemic · Phase 4
- Muscle Weakness · Phase 3
- Nephrosis, Lipoid · Phase 4
- Nephrotic Syndrome · Phase 4
- Osteoarthritis, Knee · Phase 3
- Osteoporosis · Phase 4
- Osteoporosis, Postmenopausal · Phase 4
- Pelvic Organ Prolapse · Phase 3
- Renal Insufficiency · Phase 2
- Renal Insufficiency, Chronic · Phase 4
- Sarcopenia · Phase 4
- Scoliosis · Phase 2
- Squamous Cell Carcinoma of Head and Neck · Phase 2/Phase 3
- Stomatitis · Phase 2/Phase 3
- Vascular Calcification · Phase 2
Mechanism of action
- Vitamin D receptorAGONIST
VDR agonist
Alfacalcidol is a vitamin D analog and is used for supplementation in humans and as a poultry feed additive.
Chemistry & pharmacology
Loading structure…
SMILES
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O- Mol. weight
- 400.65 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- WikipediaAlfacalcidol ↗
- ChEMBLCHEMBL1601669 ↗
Also known as
- 1 alpha-hydroxycholecalciferol
- 1alpha-hydroxycholecalciferol
- 1alpha-hydroxycholecalciferol
- 1alpha-hydroxycholecalciferol
- 1 alpha-hydroxyvitamin d3
- 1alpha-hydroxy-vitamin d3
- 1alpha-hydroxy-vitamin d3
- 1alpha-hydroxyvitamin d3
- 1alpha-hydroxyvitamin d3
- 1alpha-ohd3
- 1-alpha-oxycholecalciferol
- 1-hydroxycholecalciferol
- 1-hydroxycholecalciferol
- 1-hydroxycholecalciferol
- 1-hydroxycholecalciferol
- 1-hydroxycholecalciferol, (1alpha,3alpha-(5z,7e))-isomer
- 1-hydroxycholecalciferol, (1beta,3beta-(5e,7e))-isomer
- 1-hydroxycholecalciferol, (1beta)-(5z)-isomer
- 1-hydroxycholecalciferol, aluminum salt
- (5z,7e)-9,10-seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol
- (5z,7e)-9,10-seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol
- 9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta-diol
- 9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta-diol
- 9,10-secocholesta-,7,10(19)-triene-1 alpha,3 beta-diol
- alfacalcidiol
- alfacalcidiol
- alfacalcidol
- alfacalcidol
- alfacalcidol
- alfacalcidol
- alfacalcidol
- alfacalcidol
- alfacalcidol
- alfacalcidol
- alfacalcidol
- alfacalcidolum
- alfacalcidolum
- alfad
- alfa d
- alfakalsidol
- alfarol
- alphacalcidol
- alphacalcidol
- alpha-calcidol
- alsiodol
- alsiodol
- bondiol
- doss brand of alfacalcidol
- eenalfadrie
- einsalpha
- einsalpha
- etalpha
- etalpha
- etalpha
- oksidevit
- one-alpha
- one-alpha
- one-alpha
- un-alfa
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06385093 | Phase 4 | Jun 30, 2024 | Chinese Academy of Medical Sciences, Chinese SLE Treatment And Research Group |
| NCT06272227 | Phase 4 | Feb 13, 2024 | Yonsei University |
| NCT06016400 | Phase 2/Phase 3 (Phase 3) | Jun 14, 2021 | Sun Yat-Sen University |
| NCT05505253 | Phase 3 | Nov 1, 2020 | Padjadjaran University |
| NCT04967469 | N/A | Sep 1, 2020 | Rajavithi Hospital, Bangkok |
| NCT03582917 | Phase 2 | Sep 30, 2018 | University of Ioannina |
| NCT03210688 | Phase 4 | May 1, 2018 | Aarhus University |
| NCT04405960 | Phase 3 | Jul 1, 2017 | Syarif Hidayatullah State Islamic University |
| NCT02824718 | Phase 2 | Jun 6, 2017 | Government of France, University of Paris |
| NCT04085770 | Phase 4 | Apr 1, 2017 | Cairo University |
| NCT03292744 | Phase 4 | Jan 10, 2017 | University of Indonesia |
| NCT03147677 | Phase 4 | Jul 1, 2016 | Central South University |
| NCT03777033 | N/A | Mar 1, 2015 | Hellenic Red Cross Hospital |
| NCT02895061 | N/A | Jan 1, 2015 | Government of Thailand |
| NCT02747381 | Phase 4 | Aug 1, 2014 | Cairo University |
| NCT02993302 | Phase 2 | Jul 1, 2014 | University of Indonesia |
| NCT01974167 | N/A | Dec 1, 2013 | e-GLORIA trial Protocol Review Committee, University of Tokushima |
| NCT01896609 | Phase 4 | Jun 1, 2013 | Cairo University, MinaPharm Pharmaceuticals |
| NCT01774812 | Phase 2 | Jan 1, 2013 | Alberta Innovates Health Solutions, Canadian Institutes of Health Research (CIHR), University of Calgary |
| NCT01765010 | Phase 4 | Jan 1, 2013 | Seoul National University |
Showing 20 of 35 trials
Page 1 / 2
Organizations
Research & Development (37)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 3 | 2 | 1 | 2013 |
| University of Indonesia | Academic/Hospital | 3 | 3 | 3 | 2012 |
| Aarhus University | Academic/Hospital | 2 | 2 | 1 | 2002 |
| Mahidol University | Academic/Hospital | 2 | 2 | 2 | 2008 |
| University of Tokushima | Academic/Hospital | 2 | 0 | 2 | 2004 |
| Alberta Innovates Health Solutions | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Canadian Institutes of Health Research (CIHR) | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Central South University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Chinese SLE Treatment And Research Group | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Chinese University of Hong Kong | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Chugai | For profit | 1 | 1 | 1 | 2004 |
| e-GLORIA trial Protocol Review Committee | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Eisai | For profit | 1 | 1 | 1 | 2005 |
| Eli Lilly | For profit | 1 | 1 | 1 | 2011 |
| Government of France | Government | 1 | 0 | 1 | 2017 |
| Government of Thailand | Government | 1 | 1 | 1 | 2015 |
| Hellenic Red Cross Hospital | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Humboldt University | Academic/Hospital | 1 | 1 | 1 | 2003 |
| Isfahan University | Academic/Hospital | 1 | 1 | 1 | 2012 |
37 organizations
Page 1 / 2