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platelet rich fibrin

Biologicalexperimental

Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and leukocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and is used as a tissue-engineering scaffold in oral and maxillofacial surgeries. PRF falls under FDA Product Code KST, labeling it as a blood draw/Hematology product classifying it as 510(k) exempt. — Wikipedia

Clinical trial activity

167 trials · 96 clinical orgs · 0 marketing orgs

Phase 1
19
Phase 2
33
Phase 3
18
Phase 4
19

Earliest trial started Aug 1, 2007 (NCT00931567)

Timeline

2000s

  1. Jan 1, 2007

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2012

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • platelet rich fibrin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07294521Early Phase 1 (Phase 1)Dec 16, 2025Government of Pakistan
NCT07280507Early Phase 1 (Phase 1)Nov 24, 2025King Abdul-Aziz University
NCT07153133N/ASep 1, 2025Mansoura University
NCT07081230N/AJul 7, 2025Mansoura University
NCT06996106N/AJun 30, 2025Kafrelsheikh University
NCT06889363Phase 2Jun 30, 2025Cairo University
NCT06905860Phase 4Jun 1, 2025Federal University of Sao Paulo
NCT07150858N/AMay 25, 2025Alexandria University
NCT06914193N/AApr 1, 2025Beijing Fangshan District Liangxiang Hospital, Capital Medical University, Hengshui People's Hospital
NCT07072182N/AMar 20, 2025Mansoura University
NCT06842277Phase 2Feb 18, 2025Cairo University
NCT06964529N/AFeb 11, 2025Inonu University
NCT07242729N/AFeb 1, 2025Federal University of Sao Paulo
NCT07033351N/AFeb 1, 2025Al-Mustansiriyah University
NCT06776289Phase 4Jan 6, 2025University of Kentucky
NCT06782035N/AJan 2, 2025Izmir Katip Celebi University
NCT06894121N/ADec 18, 2024Ankara Yildirim Beyazıt University
NCT06643507Phase 2/Phase 3 (Phase 3)Nov 20, 2024Cairo University
NCT06570200Phase 2Oct 31, 2024Cairo University, University of London
NCT06567548N/AOct 31, 2024Cairo University
Showing 20 of 167 trials
Page 1 / 9

Organizations

Research & Development (96)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Cairo UniversityAcademic/Hospital292852016
Alexandria UniversityAcademic/Hospital9932018
Mansoura UniversityAcademic/Hospital8732020
Al Azhar UniversityAcademic/Hospital7752022
Ain Shams UniversityAcademic/Hospital6522012
Government Dental College and Research Institute, BangaloreAcademic/Hospital5532013
Beni Suef UniversityAcademic/Hospital4422019
Saglik Bilimleri UniversitesiAcademic/Hospital4412021
University of BaghdadAcademic/Hospital4422019
Damascus UniversityAcademic/Hospital3312017
Kafrelsheikh UniversityAcademic/Hospital3322024
Krishnadevaraya College of Dental Sciences & HospitalAcademic/Hospital3322017
The New York Eye & Ear InfirmaryAcademic/Hospital3322008
Al-Mustansiriyah UniversityAcademic/Hospital2212023
Bezmialem UniversityAcademic/Hospital2212017
Fayoum UniversityAcademic/Hospital2212018
Federal University of Sao PauloAcademic/Hospital2222025
Gazi UniversityAcademic/Hospital2112011
Izmir Katip Celebi UniversityAcademic/Hospital2212019
Kahramanmaras Sutcu Imam UniversityAcademic/Hospital2212024
96 organizations
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