pixuvri
Small moleculeexperimental
Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent. The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials. — Wikipedia
Clinical trial activity
17 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
13
Phase 3
5
Phase 4
0
Earliest trial started Dec 1, 2001 (NCT00060684)
Timeline
Indications
Studied for
Mechanism of action
- DNACROSS-LINKING AGENT
DNA cross-linking agent
Forms formaldehyde-mediated adducts with DNA (favours the CpG motif) and stimulates topoisomerase II-mediated DNA cleavage
Binds d(TCATATGA)2, d(CCGAGAATTCCGG)2 {double bulge}, d(TACGATGAGTA) : d(TACCATCGTA) {single bulge}
Chemistry & pharmacology
Loading structure…
SMILES
NCCNc1ccc(NCCN)c2c1C(=O)c1ccncc1C2=O- Mol. weight
- 325.37 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL167731 ↗
- WikipediaPixantrone ↗
- ChEMBLCHEMBL2103844 ↗
Also known as
- 5,8-bis((2-aminoethyl)amino)-2-aza-anthracene-9,10-dione
- 5,8-bis(2-aminoethylamino)-2-azaanthracene-9,10-dione
- 6,9-aea-biqdo
- 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione
- 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione
- 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione
- bbr2778
- bbr 2778
- bbr-2778
- bbr-2778
- bbr-2778
- pix
- pix
- pixantrone
- pixantrone
- pixantrone
- pixantrone
- pixantrone
- pixantrone
- pixantrone
- pixantrone dimaleate
- pixantrone dimaleate
- pixantrone dimaleate
- pixantrone dimaleate
- pixantrone dimaleate
- pixantrone dimaleate
- pixantrone maleate
- pixantrone maleate
- pixuvri
- pixuvri
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03458260 | Phase 2 | Mar 26, 2018 | The Lymphoma Academic Research Organisation, University of London, University of Paris, University of Strasbourg |
| NCT02800889 | Phase 1 | Oct 1, 2016 | CTI BioPharma, University of Southern California |
| NCT02678299 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2016 | Aarhus University |
| NCT02499003 | Phase 2 | Aug 1, 2015 | CTI BioPharma, Johannes Gutenburg University, Roche |
| NCT01632436 | Phase 1 | May 1, 2012 | CTI BioPharma, University of Texas, San Antonio |
| NCT01491841 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2011 | CTI BioPharma, Duke University |
| NCT01321541 | Phase 3 | Apr 1, 2011 | CTI BioPharma |
| NCT01086605 | Phase 2 | May 1, 2010 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT00577161 | Phase 3 | Sep 1, 2007 | CTI BioPharma |
| NCT00551239 | Phase 3 | Aug 1, 2007 | CTI BioPharma |
| NCT00268853 | Phase 2 | Nov 1, 2005 | CTI BioPharma |
| NCT00106600 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2005 | CTI BioPharma |
| NCT00060671 | Phase 3 | Jan 1, 2005 | CTI BioPharma |
| NCT00088530 | Phase 3 | Jul 1, 2004 | CTI BioPharma |
| NCT00069966 | Phase 2 | Apr 1, 2003 | Theradex, University of Nebraska |
| NCT00053105 | Phase 1 | Feb 1, 2002 | Theradex, University of Texas at Houston |
| NCT00060684 | Phase 1 | Dec 1, 2001 | CTI BioPharma |
Showing 17 of 17 trials
Page 1 / 1
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| CTI BioPharma | For profit | 12 | 10 | 3 | 2001 |
| Theradex | For profit | 2 | 2 | 2 | 2002 |
| Aarhus University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Duke University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Johannes Gutenburg University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2010 |
| National Cancer Institute (NCI) | Government | 1 | 1 | 1 | 2010 |
| Roche | For profit | 1 | 0 | 1 | 2015 |
| The Lymphoma Academic Research Organisation | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of London | Academic/Hospital | 1 | 0 | 1 | 2018 |
| University of Nebraska | Academic/Hospital | 1 | 0 | 1 | 2003 |
| University of Paris | Academic/Hospital | 1 | 0 | 1 | 2018 |
| University of Southern California | Academic/Hospital | 1 | 0 | 1 | 2016 |
| University of Strasbourg | Academic/Hospital | 1 | 0 | 1 | 2018 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2002 |
| University of Texas, San Antonio | Academic/Hospital | 1 | 0 | 1 | 2012 |
16 organizations
Page 1 / 1